Gael Cristofari Inserm Research Director, PhD Life Sciences

Course and current status

Education

2008

Degree to supervise research (HDR), ENS-Lyon, Lyon, France

2002

PhD in Life Sciences (highest honors), ENS-Lyon, Lyon, France

1999

MSc Biology (highest honors, ranked 1/45), Univ. of Lyon & ENS-Lyon, France

1999

Agrégation of Biochemistry and Biotechnology

 

 Professional Experience

2016-present

Research Director (Inserm DR2), IRCAN, Nice, France

2016-present

Deputy director, national consortium on transposable elements (CNRS GDR 3546, >40 teams)

2010-present

Founding member of and group leader at IRCAN, Nice, France

Retrotransposons and genome plasticity in cancer and aging.

2007-2009

Research associate (Inserm CR1), ENS-Lyon, Lyon, France

Regulation of cellular and viral reverse transcriptases.

2002-2007

Post-doctoral fellow, Pr Joachim Lingner’s laboratory, Swiss Institute of Experimental Cancer Research (ISREC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Swizerland.

Human telomerase and telomere homeostasis.

1999-2002

Graduate student, Pr Jean-Luc Darlix’ laboratory, ENS-Lyon, Lyon, France.

Molecular mechanisms of yeast retrotransposon replication.


Honors and Awards

2020

Henry and Mary-Jane Mitjavile Prize, French National Academy of Medicine 

2018-present

Laureate of Inserm cross-cutting program on "Genomic Variability"

2018-present

Medical Research Foundation award (FRM Team program)

2010-2014

Laureate of the European Research Council (ERC Starting Grant)

2009

Inserm Avenir award

2009

Albert Sézary Prize, French National Academy of Medicine 

2003-2004

EMBO long-term postdoctoral fellowship

2003

Jacques Piraud Prize, Medical Research Foundation (FRM)

2002

Medical Research Foundation (FRM) short-term fellowship

2000

Lyon University Prize for master students (Amis de l’Université de Lyon)

1999-2002

PhD fellowship Allocataire Moniteur Normalien

1995-1999

Studenship from Ecole Normale Supérieure de Lyon (Elève normalien).


Commissions of Trust

2020-present

Board member, Academic council of University Côte d’Azur

2019-present

Associate Editor, Mobile DNA

2018

Panel expert, High Council for Evaluation of Research and Higher Education (Hcéres)

2016-present

Ad hoc reviewer, Bioinformatics, Cell, Cell Chemical Biol, Cell Reports, Cell Res, Development, eLife, EMBO Journal, Epigenetics, Genome Biology, Genome Res, J Clin Invest, Mobile DNA, Mol Biol Evol, NAR Cancer, Nat Commun, Nat Struct Mol Biol, Nucleic Acids Res, PLoS Biology, PLoS Genet, PNAS, Stem Cell Reports, Trends in Genetics

2016-present

Board member, Scientific academy of Idex JEDI (University Côte d'Azur)

2014

Panel expert, French National Research Agency (ANR)

2014-2019

Editorial board, Mobile DNA 

2012-present

Ad hoc grant reviewer, ERC (European Research Council), Human Frontier Science Program (HFSP), Wellcome Trust UK, Medical Research Foundation UK, Biotechnology and Biological Sciences Research Council (BBSRC) UK, ANR (French National Research Agency), Swiss Cancer League CH, Massachusetts General Hospital US, Newcastle University UK, Canceropoles, and several other regional calls.

Scientific summary

Scientific interest

Cancer, as well as normal and pathological ageing, are characterized by the accumulation of genetic and epigenetic alterations. Our main interest is to understand how mobile genetic elements contribute to these alterations, and what are the functional and physiological consequences of this form of (epi)genome plasticity.

Selected Publications

- out of 45 publications; h-index: 24; total citations: 2705 [Google scholar on the 08/12/20]

  1. Lanciano S, Cristofari G. Measuring and interpreting transposable element expression. Nat Rev Genet. 2020 Dec;21(12):721-736. (review)
  2. Tristán-Ramos P, Rubio-Roldan A, Peris G, Sánchez L, Amador-Cubero S, Viollet S, Cristofari G, Heras SR. The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition. Nat Commun. 2020 Nov 11;11(1):5712.
  3. Sultana T*, van Essen D*, Siol O, Bailly-Bechet M, Philippe C, Zine El Aabidine A, Pioger L, Nigumann P, Saccani S, Andrau JC, Gilbert N, Cristofari G. (2019) The landscape of L1 retrotransposons in the human genome is shaped by pre-insertion sequence biases and post-insertion selection. Mol Cell. 74(3): 555–570 (*co-first authors)
  4. Sultana T*, Zamborlini A*, Cristofari G#, Lesage P#. (2017) Integration site selection by retroviruses and transposable elements in eukaryotes. Nat Rev Genet. 18(5): 292-308 (*co-first, #co-corresponding authors)
  5. Philippe C, Vargas-Landin DB, Doucet AJ, van Essen D, Vera-Otarola J, Kuciak M, Corbin A, Nigumann P, Cristofari G. (2016) Activation of individual L1 retrotransposon instances is restricted to cell-type dependent permissive loci. eLife. 5: e13926
  6. Mir AA, Philippe C, Cristofari G. (2015) euL1db: the European database of L1HS retrotransposon insertions in humans. Nucleic Acids Res. 43:D43-47
  7. Monot C*, Kuciak M*, Viollet S, Mir AA, Gabus C, Darlix JL, Cristofari G. (2013) The specificity and flexibility of L1 reverse transcription priming at imperfect T-tracts. PLoS Genet. 9(5):e1003499
  8. Goic B, Vodovar N, Mondotte JA, Monot C, Frangeul L, Blanc H, Dorey V, Vera-Otarola J, Cristofari G, Saleh MC. (2013) RNA-mediated interference and reverse transcription control the persistence of RNA viruses in the insect model Drosophila. Nat Immunol. 14:396-403
  9. Cristofari G, Adolf E, Reichenbach P, Sikora K, et al. (2007) Human telomerase RNA accumulation in Cajal bodies facilitates telomerase recruitment to telomeres and telomere elongation. Mol Cell. 27:882-889
  10. Cristofari G, Reichenbach P, Regamey PO, Banfi D, et al. (2007) Low- to high-throughput analysis of telomerase modulators with Telospot. Nat Methods. 4:851-853.
  11. Cristofari G, Lingner J. (2006) Telomere length homeostasis requires that telomerase levels are limiting. EMBO J. 25, 565-574
  12. Cristofari G, Bampi C, Wilhelm M, Wilhelm FX, Darlix JL. (2002) A 5'-3' long-range interaction in Ty1 RNA controls its reverse transcription and retrotransposition. EMBO J. 21(16):4368-79

 

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