Archana Singh-Manoux
  • E-mail :[email]
  • Phone : 3177747410
  • Location : Villejuif, France
Last update 2018-04-27 18:16:23.816

Archana Singh-Manoux PhD, HDR Epidemiology

Course and current status


Research Director (DR1), INSERM

Honorary Professor, University College London



2015: Prix Recherche Inserm

2010: Member, Academia Europaea, The Academy of Europe.

2005: Chair of Excellence Award: French Ministry of Research.

2005: ERC Starting Grant


10 KEY PUBLICATIONS (out of a total >300), H-index 56; top 1% highly cited scientists

  • Singh-Manoux A,  Dugravot A, Shipley M, Brunner EJ, Elbaz A, Sabia S, Kivimaki, M. Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study. Alzheimers Dement . 2017; pii: S1552-5260(17) 33689-0.  
  • Singh-Manoux A, Fayosse A, Sabia S, Canonico M, Bobak M, Elbaz A, Kivimaki M, Dugravot A. Atrial fibrillation as a risk factor for cognitive decline and dementia. Eur Heart J 2017; 38(34): 2612-2618.
  • Rusmaully J, Dugravot A, Moatti JP, Marmot MG, Elbaz A, Kivimaki M, Sabia S, Singh-Manoux A. Contribution of cognitive performance and cognitive decline to associations between socioeconomic factors and dementia: A cohort study. PLoS Med. 2017 Jun 26; 14(6): e1002334.
  • Sabia S, Dugravot A, Dartigues JF, Abell J, Elbaz A, Kivimäki M, Singh-Manoux A. Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study. BMJ. 2017; 357: j2709.
  • Singh-Manoux A, Dugravot A, Fournier A, Abell J, Ebmeier K, Kivimäki M, Sabia S. Trajectories of Depressive Symptoms Before Diagnosis of Dementia: A 28-Year Follow-up Study. JAMA Psychiatry. 2017; 74: 712-718.
  • Tuligenga RH, Dugravot A, Tabák AG, Elbaz A, Brunner EJ, Kivimäki M, Singh-Manoux A. Midlife type 2 diabetes and poor glycaemic control as risk factors for cognitive decline in early old age: a post-hoc analysis of the Whitehall II cohort study. Lancet Diabetes Endocrinol. 2014; 2: 228-35.
  • Kaffashian S, Dugravot A, Brunner EJ, Sabia S, Ankri J, Kivimäki M, Singh-Manoux A. Midlife stroke risk and cognitive decline: A 10-year follow-up of the Whitehall II cohort study. Alzheimers Dement 2013; 9: 572-9.
  • Sabia S, Elbaz A, Dugravot A, Head J, Shipley M, Hagger-Johnson G, Kivimaki M, Singh-Manoux A. Impact of smoking on cognitive decline in early old age. The Whitehall II cohort study. JAMA Psychiatry 2012; 69: 627-635.
  • Singh-Manoux A, Kivimaki M, Glymour MM, Elbaz A, Berr C, Ebmeier KP, Ferrie JE, Dugravot A Timing of onset of cognitive decline: results from Whitehall II prospective cohort study. BMJ 2012; 344: DOI: 10.1136/bmj.d7622
  • Singh-Manoux A, Marmot MG, Glymour M, Sabia S, Kivimäki M, Dugravot A. Does cognitive reserve shape cognitive decline? Ann Neurol. 2011; 70: 296–304.




  • 2015 onwards: Board of Directors, Fondation Plan Alzheimer, France.
  • 2015 onwards: Scientific Council, Fondation Recherche Medicale, France.
  • 2011-2014: Deputy Director, French Institute of Public Health (ITMO-Santé Publique)
  • 2011 onwards: Associate Editor, Journal of Epidemiology & Community Health.


RESEARCH GRANTS (a selection)

  • 2015-2018Work Package leader on Horizon 2020 (Call: H2020-PHC-2014-single-stage, PHC-31-2014), “FoResight and Modelling for European HEalth Policy and Regulation”.
  • 2009-2015Principal Investigator on grant R01AG013196 (Socio-economic status and heterogeneity in aging) from the National Institute on Aging, NIH, USA.
  • 2009-2015Principal Investigator on grant R01AG034454 (Health behaviors over the adult lifecourse and cognitive aging) from the National Institute on Aging, NIH, USA.
  • 2013-2018Co-Investigator on Grant K013351 (Adult Determinants of Late Life Depression, Cognitive Decline and Physical Functioning - The Whitehall II Study of Ageing) from the Medical research Council, MRC.
  • 2017-2021: Co-Investigator on Grant, “Vascular risk and functional decline in old age: from discovery to translation”. RG/16/11/32334, British Heart Foundation.



Scientific summary

Epidemiology of ageing and age related diseases (Team 8, CESP), Inserm U1018,

Whitehall II study, University College London,

My research is on the determinants of cognitive decline and dementia with a focus on socioeconomic, occupational, psychosocial, behavioural and biological factors. A second aspect of my work is on the social determinants of health at older ages in order to understand the mechanisms underlying inequalities in health.

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