Dr Mary Poupot born Marsan, Chargée de Recherche 1ère classe INSERM
Centre de Recherche en Cancérologie de Toulouse (UMR 1037)
Team "Immunociblage thérapeutique des hémopathies malignes B"
CHU Purpan, BP3028, 31024 Toulouse, France
University & research career:
1997 PhD thesis in Biochemistry, University Toulouse III.
1997-1998 Attachée Temporaire d'Enseignement et de Recherche, Univ. Toulouse III.
2002-2006 Post-doctoral fellowship, Centre de Physiopathologie Toulouse Purpan.
2006-2007 Junior Researcher Inserm, Centre de Physiopathologie Toulouse Purpan.
2007 Chargé de Recherche 1ère classe INSERM.
Students management and teaching:
During these last 10 years, I supervised 3 students Master 1, 7 students Master 2 research, 2 thesis (2010 and 2011), 1 thesis at the present time in her second year and 1 thesis at the present time in his first year.
From 1999, I'm responsible of the Biochemistry of the 2de year at the "Ecole d'Ingénieur de Purpan".
Member of the Scientifical Animation Comitee of the CRCT.
Member of the comitee of the cellular imaging technical facility of the "Institut Fédératif de Recherche Bio-Médicale de Toulouse".
Research biographical sketch
My fields of scientific expertise are biochemistry, pharmacology, immunology applied to the anticancer therapy.
After 3 years of thesis during which I synthesized particular plant sterols and studied it biophysical properties by Nuclear Magnetic Resonance, I stopped my researches during 3 years to have babies.
In 2001, I join Inserm U563 of Toulouse to go back to my research activities in a new domain for me: the immunology for anticancer purposes. My researches concern then the activation of the innate immune cells and more precisely the gd T lymphocytes for anti-tumor purposes.
During these last ten years, I patented and published a process allowing the quantification of the reactivity for different blood cell populations against a large panel of cancer cells. I participated also at a project which allowed us to show and patent the immunostimulant properties of synthetic azaphosphonate-capped dendrimers. These molecules have currently anti-inflammatory and anti-osteoclastic activities which could be extremely interesting in rheumatoid arthritis therapies. I was then recruited Chargée de Recherche Inserm in the Jean-Jacques Fournié team.
More recently, I showed that the tumor microenvironment has an immunosuppressor effect on the gd T lymphocytes and a pro-tumor effect by the transfer on cancer cells of molecules involved in the chemo resistance.
One aim of my current research works concerns the potentialization of the gd T lymphocytes activation for anticancer purposes, these lymphocytes having a high cytotoxic effect against cancer cells. My second aim is the study of the interactions between cancer cells and other cells of it microenvironment involved in their survey.
I am author and co-author of around forty publications (Poupot M or Marsan MP). I participated to 3 patents and exposed the results of my researches around 15 times in international and national congress.