Mary Poupot-Marsan
  • E-mail :[email]
  • Phone : +33582741662
  • Location : Toulouse, France

Version françaiseMary Poupot-Marsan

Last update 2019-02-07 09:45:39.006

Mary Poupot-Marsan PhD Biochemistry

Course and current status

Dr Mary Poupot born Marsan, Researcher (Inserm)

            Centre de Recherche en Cancérologie de Toulouse (UMR 1037)

            Team "Innovating strategies for anti-lymphoma therapies"    

          Oncopole de Toulouse, 2 avenue Hubert Curien, 31037 Toulouse, France

 

University & research career:

1997 PhD thesis in Biochemistry, University Toulouse III.

1997-1998        Attachée Temporaire d'Enseignement et de Recherche, Univ. Toulouse III.

2002-2006        Post-doctoral fellowship, Centre de Physiopathologie Toulouse Purpan.

2006-2007        Junior Researcher Inserm, Centre de Physiopathologie Toulouse Purpan.

from 2007         Permanent Researcher Inserm.

 

Students management and teaching:

During these last 10 years, I supervised  10 Master students, 5 thesis (2010, 2011, 2014, 2015, 2015), 2 thesis on going and 2 post-doc.

From 1999 to 2018, I was responsible of the Biochemistry of the 2de year at the "Ecole d'Ingénieur de Purpan".

 

Other fonctions:

- Member of the Scientifical Animation Comitee of the CRCT (national symposium and international congress organization)

- Member of the comitee of the SFR-BMT (Structure Fédérative de Recherche Bio-Médicale de Toulouse). 

- Member of the scientific comitee of the "Ligue Contre le Cancer" (scientific programs evaluation).

- Member of the scientific comitee of "Aviesan Plan Cancer" (evaluation for master, doc and post-doc salaries)

- Evaluation of scientific publication.

- Thesis comitees.

Scientific summary

Research biographical sketch

My fields of scientific expertise are biochemistry, pharmacology, immunology applied to the anticancer therapy.

After 3 years of thesis during which I synthesized particular plant sterols and studied it biophysical properties by Nuclear Magnetic Resonance, I stopped my researches during 3 years to have babies.

In 2001, I joined Inserm U563 of Toulouse to go back to my research activities in a new domain for me: the immunology for anticancer purposes. The aim of my researche was the activation of the innate immune cells and especially the gd T lymphocytes for anti-tumor purposes.

At the beginnig of the last fifteen years, I patented and published a process allowing the quantification of the reactivity for different blood cell populations against a large panel of cancer cells. I participated also in a project which allowed us to show and patent the immunostimulant properties of synthetic azaphosphonate-capped dendrimers. These molecules have currently anti-inflammatory and anti-osteoclastic activities which could be extremely interesting in rheumatoid arthritis and in other anti-inflammatory therapies. I was then recruited (2007) as Permanent Researcher Inserm in the Jean-Jacques Fournié team.

Then, I showed that the tumor microenvironment had an immunosuppressor effect on the gd T lymphocytes and a pro-tumor effect by the transfer on cancer cells of membrane molecules involved in the chemo resistance.

One aim of my current research works concerns the potentialization of the γδ T lymphocytes activation for anticancer purposes, these lymphocytes having a high cytotoxic effect against cancer cells. My second aim is to target Tumor Associated Macrophages (TAM) which are pro-tumor cells promoting tumor development and chemoresistance of cancer cells.

Valuation:

I am author and co-author of around eighty publications (Web of science, all databases) or forty publications (Pubmed). I participated to 5 patents and exposed the results of my researches around 20 times in international and national congress.

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