CV Science

Mary Poupot-Marsan PhD Biochemistry

Course and current status

Dr Mary Poupot born Marsan, Researcher (Inserm)

            Centre de Recherche en Cancérologie de Toulouse (UMR 1037)

            Team "Network Biology for Immuno-Oncology"    

          Oncopole de Toulouse, 2 avenue Hubert Curien, 31037 Toulouse, France

University & research career:

1997 PhD thesis in Biochemistry, University Toulouse III.

1997-1998        Attachée Temporaire d'Enseignement et de Recherche, Univ. Toulouse III.

2002-2006        Post-doctoral fellowship, Centre de Physiopathologie Toulouse Purpan.

2006-2007        Junior Researcher Inserm, Centre de Physiopathologie Toulouse Purpan.

from 2007         Permanent Researcher Inserm.

Students management and teaching:

From 1999 Biochemistry and chemistry courses at the "Ecole d'Ingénieur de  Purpan".

From 2007 Supervision of 12 Master students, 8 PhD students (2010, 2011, 2014, 2015, 2015, 2020, 2022, from january 2023) and 3 post-doc.

From 2019 Master courses ("Biosanté" and "Immuno-oncologie" Master) .

Other fonctions:

- Member and Animator of the Innovation Program Committee of TIRIS (Toulouse Initiative for Research's Impact on Society), an interdiscipliary program supported by the University of Toulouse

- Member of the Projects Strategic Committee at Eurobiomed

- Member of the Scientifical Animation Comitee of the CRCT (national symposium and international congress organization)

- Member of the comitee of the SFR-B2S (Structure Fédérative de Recherche en Biotechnologies et santé de Toulouse). 

- Member of the scientific comitee of the "Ligue Contre le Cancer" (scientific programs evaluation).

- Member of the scientific comitee of "Aviesan Plan Cancer" (evaluation for master, doc and post-doc salaries)

- Evaluation of scientific publication.

- Thesis comitees and jury

Scientific summary

Research biographical sketch

My fields of scientific expertise are the biochemistry, the pharmacology and the immunology applied to the anticancer therapy.

After 3 years of thesis during which I synthesized particular plant sterols and studied it biophysical properties by Nuclear Magnetic Resonance, I stopped my researches during 3 years to have babies.

In 2001, I joined Inserm U563 of Toulouse to go back to my research activities in a new domain for me: the immunology for anticancer purposes. The aim of my researche was the activation of the innate immune cells and especially the gd T lymphocytes for anti-tumor purposes.

At the beginnig of the last fifteen years, I patented and published a process allowing the quantification of the reactivity for different blood cell populations against a large panel of cancer cells. I participated also in a project which allowed us to show and patent the immunostimulant properties of synthetic azaphosphonate-capped dendrimers. These molecules have currently anti-inflammatory and anti-osteoclastic activities which could be extremely interesting in rheumatoid arthritis and in other anti-inflammatory therapies. I was then recruited (2007) as Permanent Researcher Inserm in the Jean-Jacques Fournié team.

Then, I showed that the tumor microenvironment had an immunosuppressor effect on the gd T lymphocytes and a pro-tumor effect by the transfer on cancer cells of membrane molecules involved in the chemo resistance.

One aim of my current research works concerns the potentialization of the γδ T lymphocytes activation for anticancer purposes, these lymphocytes having a high cytotoxic effect against cancer cells. My second aim is to target Tumor Associated Macrophages (TAM) which are pro-tumor cells promoting tumor development and chemoresistance of cancer cells, thanks to a patented antibody developped in the team.

Valuation:

I am author and co-author of around 85 publications (Web of science, all databases) or 53 publications (Pubmed: Poupot or Marsan). I participated to 6 patents and exposed the results of my researches around 30 times in international and national congress. I participate to Master courses in cancerologie and immunologie.