Vincent PREVOT Ph.D.

Course and current status

Education

1995-1999                 Ph.D. in Neuroscience, University of Lille, France

1994                          M.S. in Animal Physiology, University of Paris XI, Orsay, France

1993                          B.S. in Biochemistry, University of Paris XI, Orsay, France 

Professional Background

Present Appointments

2016- :    Senior Research Director (“Directeur de Recherche 1ière classe”, DR1), National Institute of Health and Medical Research (Inserm), France

2009-2017 :    Co-Director of the International Associated Laboratory NEUROBESE (Inserm - University of Lille 2 - Children's Hospital Los Angeles, University of Southern California, USA).

2006- :    Head of the Inserm Research Team “Development and Plasticity of the Neuroendocrine Brain”, Inserm U1172 (former Inserm UMR837, 2006-2014)

Previous Appointments

2009-2015   Research Director (“Directeur de Recherche 2ième classe”, DR2), Inserm, France.

2002-2009    Associate Researcher (“Chargé de Recherche”), Inserm, France

1999-2002     Postdoctoral Fellow, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon. Laboratory of Dr. Sergio R Ojeda Laboratory.

1995-1999      French Ministry of Research Doctoral Trainee. Inserm, Lille, France. Laboratory of Dr. Jean-Claude Beauvillain (Inserm    U422).

 

Honors and Awards

2018              European Research Council (ERC) Synergy Grant Laureate.

2018              Jacques Benoit Lecture at the 9th International Congress in Neuroendocrinology, Toronto,Canada

2017              Grand Prix Kuhlmann, Société des Sciences, de l'Agriculture et des Arts de Lille           

2017              Plenary lecture at the 27th meeting of the Hellenic Society for Neuroscience, Athens

2015              Plenary lecture at the 12th meeting of the French Society for Neuroscience, Montpellier

2014-2017     Inserm award for the Excellence of Research

2007-2012     Contract for translational research, Inserm –Lille County Hospital

2000               “Inserm 2000” postdoctoral fellowship

1996               Doctoral fellowship from the French Ministry of Research

 

Election and nomination to Executive Committees and Advisory Boards

2017-2019          Nominated member at the Life and Health Science study section (SVS-3) at the  F.R.S.-FNRS (Fond de la Recherche Scientifique), Belgium.

2016-present      Nominated member at the Neuroscience Study Section at Inserm (CSS4), France. 

2015-2017          Treasurer of the Federation of European Neuroscience Societies (FENS)

2014- present     Member of the Scientific Council of the French Medical Research Foundation (FRM)

2013-2015          President of the French Society for Neuroendocrinology

2013- 2014         Member of the Institute National de la Recherche Agronomique (INRA) commission for the recruitment of tenured track INRA Research Associate and Directors.

2012-2017          Scientific council of the "DIM Cerveau et Pensée & DIM Neuropole de Recherche Francilien (NeRF)", Paris, France

2012-2017          Member of the Executive Committee of the Federation of European Neuroscience Societies (FENS)

2012-2015          Member of the Council of the International Neuroendocrinology Federation

2012-2018          Member of the board of the French Glial Cell Club

2008-2009          Treasurer of the French Society for Neuroscience

2009-2011          Treasurer of the French Society for Neuroendocrinology               

2006-2011          Member of the board of the French Society for Neuroendocrinology

2006-2009          Member of the board of the French Society for Neuroscience

 

Administrative Responsibilities

2006-present      Member of the Board of Directors of the Jean-Pierre Aubert Research Center

2008-2013          Member of the Institutional Animal Care and Use Committee of the University of Lille.

2006- 2011         Scientific Director of the “Biserte” animal facility of the federative research Institute of the University of Lille 2 (IFR 114).

 

Editorial Boards

2016-  :                  Associate Editor for Reviews, Neuroendocrinology (IF: 5)

2014-   :                 Editorial board of Endocrinology (IF: 4)

2011-present:        Editorial board of the Journal of Neuroendocrinology (IF: 3.4)

2008-present :       Contributing Editor of the European Journal of Neuroscience (EJN) (IF: 2.8)

2010                      Invited editor of the EJN special issue on "Plasticity of Neuroendocrine systems" Volume 32, number 12.

 

Selected Symposia and Lectures out of 70

  1. British Journal of Pharmacology’s symposium ‘Celebrating the 20-year birthday of the Nobel Prize for NO: the legacy continues’. "When the hypothalamus says NO: a role for nitric oxide in fertility, olfaction and cognition", Symposium at the British Pharmacological Society’s annual meeting, London, UK, December 2018.
  2. Keystone Symposia Conference: Drivers of Type 2 Diabetes: From Genes to Environment. "Role of Hypothalamic Tanycytes in Metabolic Homeostasis", Symposium, Seoul, South Korea, October 2018.
  3. 9th International Congress in Neuroendocrinology. "The versatile tanycyte: a hypothalamic integrator of reproduction and energy metabolism". Jacques Benoit Lecture, Toronto, Canada, July 2018.
  4. Neuroendocrine Interfaces in Physiology and Disease, Nobel Forum, "The versatile tanycytes: controlling metabolism at the brain-periphery interface", Symposium, Karolinska Institutet, Stockholm, March 2018.
  5. 27th Meeting of the Hellenic Society for Neuroscience "The gentle art of saying NO: how nitric oxide gets things done in the neuroendocrine hypothalamus", Plenary Lecture, National & Kapodistrian University of Athens, Athens, Greece, December 2017.
  6. ENDO2017 "MicroRNA regulation of GnRH neurons", Symposium, Orlando, FL, USA, April 2017.
  7. Cold Spring Harbor Laboratory: Blood Brain Barrier Meeting "Tanycytes gate blood-borne metabolic signal access to the brain", Symposium. Cold Spring Harbor, NY, USA, December 2016.
  8. 17th International Congress of Endocrinology (ICE.CSE 2016), "MicroRNA, GnRH release, and GnRH neuronal development", Symposium. Beijing, China, August 2016.
  9. XII European Meeting on Glial Cells in Health and Disease, "Tanycytes: the hypothalamic hyperdrive for hormones ", Symposium. Bilbao, Spain, July 2015
  10. 17th European Congress of Endocrinology (ECE2015), "Hypothalamic tanycytes in metabolic regulation". Symposium. Dublin, Ireland, May 2015. 

Scientific summary

The two principal focuses of our research are the Central Control of Energy Homeostasis, and the Neurobiology of Reproduction. Among our pioneering studies are: (i) the demonstration that tanycytes, specialized ependymoglial cells lining the floor of the third ventricle, are responsible for the transport of peripheral metabolic signals such as leptin across brain barriers into the metabolic brain, elucidating a mechanism for leptin resistance in obesity; (ii) the discovery that endothelial cell-derived chemotropic factors of the semaphorin family control GnRH axonal growth in the adult neuroendocrine brain, thus modulating fertility; (iii) the finding that a discrete neuronal population that releases nitric oxide in the preoptic region of the hypothalamus is vital for the rapid integration and transmission of both gonadal and metabolic signals within the neuroendocrine brain, and thus plays a key role in the timing of puberty onset; and (iv) the uncovering that a dramatic switch in miRNA expression patterns in infantile GnRH neurons inverts the balance between inductive and repressive signals, triggering increased hypothalamic GnRH expression and controlling the crucial transition from the early infantile phase, when its levels are low, to the GnRH-fuelled run-up to puberty.

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