Vincent PREVOT Ph.D.

Course and current status


1995-1999                   Ph.D. in Neuroscience, University of Lille, France

1994                           M.S. in Animal Physiology, University of Paris XI, Orsay, France

1993                            B.S. in Biochemistry, University of Paris XI, Orsay, France 

Professional Background

Present Appointments

2016- :    Senior Research Director (“Directeur de Recherche 1ière classe”, DR1), National Institute of Health and Medical Research (Inserm), France

2009- :    Co-Director of the International Associated Laboratory NEUROBESE (Inserm - University of Lille 2 - Children's Hospital Los Angeles, University of Southern California, USA).

2006- :    Head of the Inserm Research Team “Development and Plasticity of the Neuroendocrine Brain”, Inserm U1172 (former Inserm UMR837, 2006-2014)

Previous Appointments

2009-2015   Research Director (“Directeur de Recherche 2ième classe”, DR2), Inserm, France.

2002-2009    Associate Researcher (“Chargé de Recherche”), Inserm, France

1999-2002     Postdoctoral Fellow, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon. Laboratory of Dr. Sergio R Ojeda Laboratory.

1995-1999      French Ministry of Research Doctoral Trainee. Inserm, Lille, France. Laboratory of Dr. Jean-Claude Beauvillain (Inserm    U422).

Election to Executive Committees and Advisory Boards

2015-present      Treasurer of the Federation of European Neuroscience Societies (FENS)

2014- present     Member of the Scientific Council of the French Medical Research Foundation (FRM).

2013-2015          President of the French Society for Neuroendocrinology 

2013- 2014         Member of the Institute National de la Recherche Agronomique (INRA) commission for the recruitment of tenured track INRA Research Associate and Directors.

2012-present       Member of the Executive Committee of the Federation of European Neuroscience Societies (FENS)

2012-2015           Member of the Council of the International Neuroendocrinology Federation

2012-present        Member of the board of the French Glial Cell Club

2008-2009            Treasurer of the French Society for Neuroscience

2009-2011            Treasurer of the French Society for Neuroendocrinology             

2006-2011             Member of the board of the French Society for Neuroendocrinology

2006-2009             Member of the board of the French Society for Neuroscience 

Administrative Responsibilities

2006-present          Member of the Board of Directors of the Jean-Pierre Aubert Research Center

2008-2013              Member of the Institutional Animal Care and Use Committee of the University of Lille.

2006- 2011             Scientific Director of the “Biserte” animal facility of the federative research Institute of the University of Lille 2 (IFR 114).

Honors and Awards

2014-2017               Inserm award for the Excellence of Research

2007-2012               Contract for translational research, Inserm –Lille County Hospital

2000                         “Inserm 2000” postdoctoral fellowship

1996                         Doctoral fellowship from the French Ministry of Research

Editorial Boards

2016-  :                            Associate Editor for Reviews, Neuroendocrinology (IF: 2.6)

2014-   :                           Editorial board of Endocrinology (IF: 4.2)

2011-2013, 2016-present:  Editorial board of the Journal of Neuroendocrinology (IF: 3.2)

2008-present :                   Contributing Editor of the European Journal of Neuroscience (EJN) (IF: 3.0)

2010                                  Invited editor of the EJN special issue on "Plasticity of Neuroendocrine systems" Volume 32, number 12.

Selected Symposia and Lectures out of 50

  • 17th International Congress of Endocrinology, MicroRNAs, GnRH release, and GnRH neuronal development, Symposium, Beijing, China, Septembre 2016.
  • Neurosciences in Intensive Care International Symposium 2016 (NICIS2016), "CSF Barriers in Neuroinflamation", Symposium. Institut Pasteur, Paris, France, June 2016.
  • 13th Annual Meeting of the Androgen excess and PCOS Society. "miRNAs, GnRH and PCOS", Symposium, Siracusa, Italy, October 2015.
  • XII European Meeting on Glial Cells in Health and Disease, "Tanycytes: the hypothalamic hyperdrive for hormones ", Symposium. Bilbao, Spain, July 2015
  • 11th International Conference on Cerebral Vascular Biology. "Tanycytes gate blood-borne metabolic signal access to the brain". Symposium. Paris, France, July 2015
  • European Society for Pediatric Endocrinology (ESPE) Science School 2015 on Non-coding RNA in Paediatric Endocrinology. miRNA and GnRH neurons. Lecture. Annecy, France, June 2015.
  • 12th Colloque de la Société des Neurosciences, "Tanycytes: a Blood-Brain bridge for metabolic signals", Plenary Lecture. Montpellier, France, May 2015.
  • 17th European Congress of Endocrinology (ECE2015), "Hypothalamic tanycytes in metabolic regulation". Symposium. Dublin, Ireland, May 2015.
  • COST Action BM1105 on “GnRH deficiency” scientific meeting. Symposium. "Tanycytes as Gatekeepers of the Metabolic Brain, Prato, Italy, April 2015.
  • 53rd Endocrine Society for Pediatric Endocrinology (ESPE) Meeting, “Non Coding RNA's: Introduction to Non-Coding RNAs and the Role of MicroRNAs in GnRH Neurons". Symposium. Dublin, Ireland, September 2014.
  • 16th International Congress of Endocrinology & The Endocrine Society’s 96th Annual Meeting. "NO and neuromodulatory control of reproduction”. Symposium. Chicago, IL, USA, June 2014
  • FENS/IBRO/COST Training School in Neuroendocrinology. Lecture “Leptin and puberty”. Organizer and Chairperson, Prato, Italy, July 2013.
  • British Neuroscience Association (BNA) 2013: Festival of Neuroscience. “Cyclical activity of hypothalamic GnRH neurones” Symposium in a session entitled “Timing in Neuroendocrinology”, London, UK, April 2013.
  • American Society for the Study of Reproduction (SSR). "Semaphorin 3A/Neuropilin-1 signaling mediates GnRH system development and plasticity", Symposium, Philadelphia, USA, August 2012.
  • 22nd Annual Winter Conference on Neural Plasticity. "Hypothalamic vascular glial plasticity in control of neuroendocrine synapse formation." Symposium. Aruba, Caribbean, February 2010.
  • 41st Annual American Society for Neurochemistry Meeting. "Hypothalamic vascular glial plasticity in control of neuroendocrine synapse formation." Symposium (Chairperson of the symposium entitledHypothalamic plasticity: a complex and multifaceted problem”), Santa Fe, New Mexico, USA, March 2010.
  • International Congress of Neuroendocrinology. Neuronal-glial-endothelial interactions and GnRH neurons. Symposium, Rouen, France, July 2010.
  • 91st Annual Meeting of the Endocrine Society. “Neuro-glial-endothelial interactions and GnRH release in the median eminence of the hypothalamus.” Symposium, Washington, DC, USA, June 2009.


Scientific summary

The two principal focuses of our research are the Central Control of Energy Homeostasis, and the Neurobiology of Reproduction. Among our pioneering studies are: (i) the demonstration that tanycytes, specialized ependymoglial cells lining the floor of the third ventricle, are responsible for the transport of peripheral metabolic signals such as leptin across brain barriers into the metabolic brain, elucidating a mechanism for leptin resistance in obesity; (ii) the discovery that endothelial cell-derived chemotropic factors of the semaphorin family control GnRH axonal growth in the adult neuroendocrine brain, thus modulating fertility; (iii) the finding that a discrete neuronal population that releases nitric oxide in the preoptic region of the hypothalamus is vital for the rapid integration and transmission of both gonadal and metabolic signals within the neuroendocrine brain, and thus plays a key role in the timing of puberty onset; and (iv) the uncovering that a dramatic switch in miRNA expression patterns in infantile GnRH neurons inverts the balance between inductive and repressive signals, triggering increased hypothalamic GnRH expression and controlling the crucial transition from the early infantile phase, when its levels are low, to the GnRH-fuelled run-up to puberty.

Image d’exemple