Vincent PREVOT Ph.D.

Course and current status

Education

1995-1999:      Ph.D. in Neuroscience, University of Lille, France

1994:             M.S. in Animal Physiology, University of Paris XI, Orsay, France

1993:             B.S. in Biochemistry, University of Paris XI, Orsay, France

Professional Background 

Present Appointments

2006-Present:   Head of the Inserm Research Team “Development and Plasticity of the Postnatal Brain”, Inserm U837, Jean-Pierre Aubert Research Centre.

2009-Present:   Research Director at Inserm

2002-2009:       Tenured Assistant Professor (“Chargé de Recherche”), French National Institute of Health and Medical Research (Inserm)

Previous Appointments

1999-2002:        Postdoctoral Fellow, Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon. Dr. Sergio R Ojeda Laboratory.

1995-1999:         French Department of Research Predoctoral Trainee. Inserm, Lille, France. Dr. Jean-Claude Beauvillain Laboratory (Inserm U422).

Boards of Directors

2008-2009:          Treasurer of the French Society for Neuroscience

2009-2011:          Treasurer of The French Society for Neuroendocrinology  

Editorial boards

2008-Present: Contributing Editor in the European Journal of Neuroscience (EJN)

2010: Invited editor of the EJN special issue on « Plasticity of Neuroendocrine systems » Volume 32, number 12.

2011-Present: Editorial board of the Journal of Neuroendocrinology

Manuscript Reviews

Science, Endocrinology, European Journal of Neuroscience, Journal of Clinical Endocrinology & Metabolism, Journal of Neuroendocrinology, Neuroendocrinology, Journal of Physiology, Journal of Neurochemistry, Journal of comparative neurology, Biol Psychiatry, Neuroscience, Peptide, Brain research

Society Memberships 

National

• French Society of Neuroscience, 1998-present

• French Society for Neuroendocrinology, 1998-present

International

• Federation of European Neuroscience Society (FENS), 1998-present

• International Neuroendocrine Federation (INF), 2004-present

• Society for Neuroscience (SFN), 2000-present

• The Endocrine Society, 2000-present

Invited symposia

  1. British Society for Endocrinology (BES 2011). "The role of tanycytes in the regulation of the reproductive axis”, Symposium, Birmingham, UK, April 2011.
  2. British Society for Neuroendocrinology annual meeting (BSN 2011), "Neuropilin-1 mediates GnRH system development and plasticity", Symposium, Cambridge, UK, July 2011. 
  3. 10th biannual Meeting of the French Society for Neuroscience. "Ovarian-cycle-linked changes in semaphorin 3A signalling controls GnRH axon plasticity in the hypothalamus” Symposium. (Chairperson of the symposium entitledSemaphorins in the developing and postnatal brain ”), Marseille, France, May 2011.
  4. Function and Development of the Pituitary and Hypothalamus Meeting, "Endothelial cells as acontrol switch in the median eminence coordinating neurohormone release ?" and "Postnatal gliogenesis is required for female sexual maturation and adult reproductive function", Symposia. Oxford, UK, September 2010.
  5. 22nd annual meeting Winter Conference on Neural Plasticity. "Hypothalamic vascular glial plasticity in control of neuroendocrine synapse formation." Symposium. Aruba, Caribbean, February 2010.
  6. 41st Annual American Society for Neurochemistry Meeting. "Hypothalamic vascular glial plasticity in control of neuroendocrine synapse formation." Symposium (Chairperson of the symposium entitledHypothalamic plasticity: a complex and multifaceted problem”), Santa Fe, New Mexico, USA, March 2010.
  7. International Congress of Neuroendocrinology. Neuronal-glial-endothelial interactions and GnRH neurons. Symposium, Rouen, France, July 2010.
  8. Aberdeen Neuroscience Meeting IV. “Glial cells as a master control switch in the brain coordinating hormone release.” Symposium, Aberdeen, Scotland, UK, November 2009.
  9. 91st Annual Meeting of the Endocrine Society. “Neuro-glial-endothelial interactions and GnRH release in the median eminence of the hypothalamus.” Symposium, Washington, DC, USA, June 2009.
  10. International Society for Autonomic Neuroscience 2009 (ISAN2009). " Control of neuronal functions by the endothelium in the autonomic and neuro-endocrine brain". Symposium, Sydney, Australia, September 2009.
  11. Queenstown Molecular Biology Meetings: Reproductive Biology. Neuro-glial-endothelial interactions and the neuroendocrine control of female reproduction. Symposium. Queenstown, New Zeeland, September 2009.
  12. IXth European Meeting on Glial Cell in Health and Disease (Euroglia) "Glial cell plasticity: from physiology to cancer stem cells", symposium (Chairperson) Paris, France, September 2009.
  13. International Symposium on “Molecular Aspects of Brain Aging and Neurological Disorders” and Annual Meeting of Indian Society for Neurochemistry.  Neural plasticity in the sexual brain. Symposium. Amritsar, India, novembre 2008.
  14. PENS-Blackwell Sumer School: Advanced Course in Neuroplasticity. “Neuronal-glial-endothelial interactions and cell plasticity in the postnatal hypothalamus: implications for the neuroendocrine control of reproduction”. Lecture. Rome, Septembre 2007.

Scientific summary

The research undertaken in my laboratory uses a combination of genetic, primary cell culture and co-culture, biochemical, electrophysiological, neuroanatomical, immunofluorescent, electron microscopy, advanced imaging techniques and physiological approaches to study neuronal-glial-endothelial communication processes regulating GnRH neurosecretion, endothelial and neuronal nitric oxide signaling, glial erbB signalling, onset of puberty, ovarian cycle-induced brain plasticity and reproduction. In parallel, we are interested in studying how peripheral hormones (estrogen, leptin, insulin…) impact hypothalamic development and function as well as in determining the importance of non-neuronal cells (tanycytes, astrocytes and endothelial cells) in this dialogue, which is set between the periphery and the central nervous system. Our researches also evaluate how pathologies (such as obesity, diabetes) may affect these neurobiological events and, conversely, how impairment of brain communication with the periphery renders the organism prone to develop pathologies (obesity, diabetes, precocious and/or delayed puberty, and infertility). 

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