Cristine Alves da Costa (CAC) is graduated in Pharmacy-Biochemistry and has obtained and a PhD in Toxicology at the University of Sao Paulo, USP, Brazil. In 1998 she moved to France to perform a post-doctoral stage at the laboratory of Frédéric Checler, IPMC-CNRS, Valbonne, France where she has got a permanent position as a Senior Research Associate (CR1) at INSERM in 2004. Actually she holds a junior Director of Research, (DR2-INSERM, IPMC-CNRS) position and drives a team interested in the role of Parkinson's disease associated genes in the etiology of two opposite disease processes that are Parkinson's disease and brain tumors. CAC has authored 50 articles (see main partial PubMed publication records concerning the last ten years work), is reviewer of several journals and is a permanent editorial board member of several open access journals like Current Neuropharmacology, Clinical Medicine: geriatrics and Parkinson’s disease
Our team's research interests include Parkinson’s molecular and cell biology, apoptosis and p53. We are particularly interested in the study of the role Parkinson’s disease associated proteins in the etiology of the specific dopaminergic cell death observed in Parkinson's disease. Moreover several of our projects aim the delineation of specific and common signaling cascades that ultimately lead to cell death in Parkinson's and Alzheimer's disease. This transversal experimental approach aims the establishment of common molecular denominators and by consequence the identification of potential therapeutic targets. Moreover, given the inverse correlation between neurodegenerative disorders and cancer we are also interested in the role of familial PD gene products in the development of glioblastomas.