1998-2000 Post-Doc at Biozentrum (Basel): structure and function of porins
Since 2000: Maître de Conférences (Associate Professor) at Toulouse III University
We propose to explore the molecular mechanisms of the early phase of the HIV infection. This project is developed in collaboration with Dr. Arenzana’s team (Pasteur Institute) and relies on a combination of original biophysical and pharmacological approaches that our laboratories have recently developed. To address this question, we analyze the dynamic organization of CCR5 and CXCR4 in biological membranes by Single Molecule Tracking (SPT) experiments on transfected cell lines and primary T CD4+ lymphocytes.
We are studying membrane fusion induced by diacylglycerol production within nuclear membrane formation. We are working on sea urching model to perform Förster Resonance Energy Transfer (FRET) experiment analysed by Fluorescence Lifetime Imaging Microscopy (FLIM)