Régis Nouvian
  • E-mail :[email]
  • Phone : 00 33 (0)4 99 63 60 45
  • Location : Montpellier, France
Last update 2014-01-22 09:21:16.97

Régis Nouvian PhD

Course and current status

2008              Research Associate (CR Cnrs), Inserm U1051

                     Institute for Neurosciences of Montpellier, France

 

2004-2008     Postdoctoral fellow, InnerEarLab (Pr. Tobias Moser)

                     University of Göttingen, Germany

 

2004              PhD, Inserm U254 (Supervisor: Pr. Jean-Luc Puel)

                     University Montpellier, France

Scientific summary

Inner hair cells are the sensory cells of the cochlea, the organ of hearing. Inner hair cells transduce sound-stimulation into the neurotransmitter release onto the afferent auditory nerve fibers. Our current research consists to decipher the molecular determinants of hair cells exocytosis using multi-disciplinary approaches from molecular biology to system level examination.

We previously shown that the inner hair cell synaptic machinery is not conventional: hair cells express Vglut3, the vesicular transporter type 3, to load glutamate into the synaptic vesicles (Ruel et al., AJHG, 2008). This contrasts with the broad expression of Vglut1 or Vglut2 in the excitatory synapses of the brain. In addition, the calcium sensor for synaptic fusion in hair cell is most likely to be Otoferlin, and not the synaptotagmin family members, the classical and major calcium sensor for exocytosis (Roux et al., Cell, 2006). Finally, inner hair cells do not use SNAREs proteins for synaptic fusion, in contrast to the synapses of the nervous system (Nouvian et al., Nature Neuroscience, 2011).

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