né en 1970
Professor Associate at University Paris Sud 11 - INSERM U757
Bâtiment 440/443, rue des Adèles
2006-2009: INSERM U718 Paris
2002-2006: Dept of Pharmacology, University of Cambridge, UK
2001: INSERM U426 Paris
2012: Habilitation à Diriger des Recherches (University Paris Sud 11)
1999: PhD University of Reims
For the last 15 years, I have studied the functions of the leukocyte Ca2+ channels. These channels open after the emptying of the Ca2+ ions of the endoplasmic reticulum, and are known as "store-operated Ca2+ channels". The absence of the store-operated Ca2+ entry ("SOCE") leads to severe combined immunodeficiencies. Recently, the two main proteins responsible for the SOCE were characterized: STIM1 and Orai1.
My main project is to develop new effectors of the SOCE to control the activity of the leukocytes, and thereafter the immun system. This kind of effectors could also be interesting to control the proliferation of some cancerous cells where the Orai1 channel is the main Ca2+ entry (lymphomas, leukemias, breast cancers...).
I am also interested in pathologies associated with a disturbance of the Ca2+ signalling. Thus, with collaborators, we showed that the Epstein-Barr virus takes the control of the B cell Ca2+ homeostasis.
Domains of expertise
Ca2+ channels of leukocytes