• E-mail :[email]
  • Phone : +33 1 69 15 59 49
  • Location : Orsay, France
Last update 2012-05-15 17:48:45.028

Olivier DELLIS PhD Biology and Pharmacology

Course and current status

né en 1970

Current position:

Professor Associate at University Paris Sud 11 - INSERM U757

Bâtiment 440/443, rue des Adèles

91405 Orsay

Past appointments:

2006-2009: INSERM U718 Paris

2002-2006: Dept of Pharmacology, University of Cambridge, UK

2001: INSERM U426 Paris

Diplomas

2012: Habilitation à Diriger des Recherches (University Paris Sud 11)

1999: PhD University of Reims

Scientific summary

For the last 15 years, I have studied the functions of the leukocyte Ca2+ channels. These channels open after the emptying of the Ca2+ ions of the endoplasmic reticulum, and are known as "store-operated Ca2+ channels". The absence of the store-operated Ca2+ entry ("SOCE") leads to severe combined immunodeficiencies. Recently, the two main proteins responsible for the SOCE were characterized: STIM1 and Orai1.

My main project is to develop new effectors of the SOCE to control the activity of the leukocytes, and thereafter the immun system. This kind of effectors could also be interesting to control the proliferation of some cancerous cells where the Orai1 channel is the main Ca2+ entry (lymphomas, leukemias, breast cancers...).

I am also interested in pathologies associated with a disturbance of the Ca2+ signalling. Thus, with collaborators, we showed that the Epstein-Barr virus takes the control of the B cell Ca2+ homeostasis.

 

Domains of expertise

Ca2+ signalling

Ca2+ channels of leukocytes

Image d’exemple