Alain EYCHENE
  • E-mail :[email]
  • Phone : +33 1 69 86 30 74
  • Location : Orsay, France
Last update 2014-02-01 14:39:01.734

Alain EYCHENE PhD

Course and current status

Current positions:

 

Group leader at Institut Curie

INSERM U1021 - CNRS UMR3347

Tel: 33-1 69.86.30.74

E-mail : eychene@curie.fr

Since 2013: Scientific Deputy Director at INSB - CNRS

Since 2012: Deputy Director of ITMO Cancer - AVIESAN

Since 2012: Délégué Scientifique Cancer à l'INSB - CNRS

Since 2012: Member of the Cancer Committee – Fondation de France

2012 - 2013 : Member of the “Commission Scientifique n°4” of Fondation ARC (Association pour la Recherche sur le Cancer)

Since 2011: Member of the Steering Committee of the GMFMel (groupe multidisciplinaire français sur le mélanome cutané).

Since 2011: Member of the GDRI (groupement de recherche international) France Japan Cancer - CNRS

2009 - 2012 : Member of the « Commission Scientifique » of Institut Curie Research Center.

Since 2009: Member of ESPCR (European Society for Pigment Cell Research).

 

Education, training and employment:

2014: DR1 - INSERM

2001: DR2 (Research Director) - Permanent position at INSERM.

2000: Group leader at Institut Curie.

1999: Formation spéciale à l’expérimentation animale (niveau I); Ecole Nationale Vétérinaire d’Alfort.

1998: Habilitation à Diriger les Recherches (Post-Doctoral Degree). Université Paris XI.

1995: CR1 - Permanent position at INSERM.

1991: CR2 - Permanent position at INSERM.

1986-1990: PhD in Microbiology (speciality: virology). University Paris VI.

Laboratory of Dr Calothy; CNRS URA 1443 ; Institut Curie.

1985-1986: Master’s degree in Microbiology (speciality : virology). University Paris VI. Course of General Virology, Institut Pasteur, Paris. Laboratory of Dr Scherrer; Institut Jacques Monod, Paris VII.

1984: 6-months training in the Laboratory of Dr Richaud; Institut de Microbiologie, Paris XI.


Scientific summary

Major scientific contributions:

 

Alain Eychène’s lab has contributed for several years in depicting the relationships between the components of the Ras/Raf/MEK/ERK pathway. Major findings include the demonstration that KSR, a distantly related member of the Raf family, modulates the Ras/Raf/MEK/ERK pathway through binding to MEK (Denouel-Galy 1998 Curr.Biol. 8:46). Alain Eychène also contributed to the identification of BRAF thanks to its retroviral transduction (Marx 1988 EMBO J., 7:3369; Eychène 1992 Oncogene, 7:1315). A close collaboration with Dr Ballotti disclosed for the first time the involvement of B-Raf protein in the biology of melanocytes (Busca 2000 EMBO J., 19:2900). Within the frame of other collaborative projects, the team contributed to establishing the major role for B-Raf during melanoma progression. (Laud 2003 Cancer Res., 63:3061; Calipel 2003 J.Biol.Chem., 278:42409; Kannengiesser 2008 Mol.Oncol., 1:425). Ongoing projects are addressing the role of Raf proteins in melanocyte stem cells and melanoma using conditional knockout mice (Valluet 2012 Cell Reports, 2:774). In addition, Alain Eychène’s lab provided recent major contributions in the field of Maf transcription factors, by demonstrating the importance of phosphorylation in the regulation of these oncoproteins and in their oncogenic activities (Rocques 2007 Mol.Cell, 28:584; Eychène 2008 Nat.Rev.Cancer, 8:683).

Image d’exemple