CV Science

Guillaume VOGT PhD

Course and current status

2001-2002: Research Internship,

Institut Pasteur, Paris, France & University Paris XI, Orsay, France 

2002-2007: PhD Student,

INSERM U550, Necker Medical School, University Paris Descartes, France Heads: Jean-Laurent Casanova and Laurent Abel 

2007-2010: Postdoctoral Fellow,

Laboratory of Molecular Mechanisms of Innate Immunity, Weill Medical College of Cornell University, New York, New York, USA

Head: Carl Nathan 

2010-2011: Postdoctoral Associate, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, New York, USA

Head: Jean-Laurent Casanova

2011-present: INSERM CR

Human Genetics of Infectious Diseases, INSERM / Université Paris Descartes - Unité 980, Faculté de Médecine Necker, Paris FRANCE

Head: Laurent Abel

Research Associate, St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller University, New York, New York, USA

Head: Jean-Laurent Casanova

Scientific summary

I was born in France, in 1977. I received a Ph.D. degree from the University Paris René Descartes, Necker-Enfants Malades Medical School, Paris, France, in 2007. I dedicated my doctoral work in Mendelian predisposition syndrome with mycobacterial infections and mutations IFNGR2. My work has opened two new avenues of research, the discovery of mutations "gain of glycosylation" and the complementation of other mutations by inhibitors of glycosylation, distinct from the genetic complementation. Then, I worked as postdoctoral associate in Weill Medical College of Cornell University, New York, USA I have spent my post-doctoral fellowship to study the cellular mechanisms that control tuberculous mycobacteria inside human macrophages in vitro, because there was no robust protocol. I found the first culture conditions of human macrophages for destruction of mycobacteria. The prospects offered by this study are important, including the ability to identify new antimycobacterial macrophage signaling pathways, and to discover genes contributing to the induced antimycobacterial defense in humans. Recently, I joined the Rockefeller University, as Research assiatant, New York, USA, as part of the St. Giles Laboratory of Human Genetics of Infectious Diseases directed by Pr. Jean-Laurent Casanova and in Paris in the same laboratory  directed by Dr. Laurent Abel as CR INSERM. Among various distinctions, he received the distinguished Thermo (Electron Corporation) Prize (formerly Jouan Prize) in Biotherapy, and the Prize of Pediatric Pathology, Association for Study of Pediatric Pathology, Paris, France. I currently attend to describe the first genetic etiology of Whipple’s Disease.