Nathalie Andrieu-Abadie
  • E-mail :[email]
  • Phone : +33 5 61 32 35 31
  • Location : Toulouse, France
Last update 2014-03-19 17:13:42.032

Nathalie Andrieu-Abadie PhD

Course and current status

  DR2, Inserm Senior scientist

Office address

Inserm UMR1037 (Team 4) Director : Prof. Jean-Jacques Fournié

Cancer Research Center of Toulouse - Toulouse III University

CHU Rangueil, BP84225, 31432 Toulouse Cedex 4, France


Education and training

1994-1997 : Ph.D in Human Pathophysiology Toulouse III University, Toulouse, France. (with honors). Director : Prof. Robert Salvayre  (Inserm U 466)

1996 : Doctoral training Duke University, Durham, North Carolina, USA. Director : Prof. Yusuf A Hannun

1998-1999 : Post-Doctoral Fellow, Inserm U.460, Paris, France. Director : Prof. Jean-Baptiste Michel

1999-present : French National Health and Medical Research Institute- INSERM- Investigator CR2, INSERM Research Investigator

2002: Habilitation to Supervise Research Toulouse III University, Toulouse, France.


Awards and expertise

Member of jury for Master‘s degree and PhD

Member of Selection Committee MCU,MCU/PH and PU/PH

Expert for AERES and ANR

Reviewer for: Biochem J, Biochim Biophys Acta, FASEB J, J Biol Chem, J Invest Dermatol, J Neurochem and Oncogene.

Editorial Board member of the American Journal of Cancer Research since 2010.


Teaching activities

Lecturing in Human Pathophysiology and Oncology (Master’s and Postgraduate degrees)

Paul Sabatier University of Toulouse, France


5 Selected Publications

Tardy C, Tyynelä J, Hasilik A, Levade T, Andrieu-Abadie N. Stress-induced apoptosis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D. Cell Death Diff (2003) 10, 1090-1100.

Autefage H, Albinet V, Garcia V, Berges H, Nicolau M-L, Therville N, Altié M-F, Caillaud C, Levade T, Andrieu-Abadie N. The lysosomal serine protease CLN2 regulates TNF alpha-mediated apoptosis in a bid-dependent manner. J Biol Chem (2009) 284, 11507-16.

Colié S, Van Veldhoven PP, Kedjouar B, Bedia C, Albinet V, Sorli SC, Garcia V, Djavaheri-Mergny M, Bauvy C, Codogno P, Levade T, Andrieu-Abadie N. Disruption of sphingosine 1-phosphate lyase confers resistance to chemotherapy and promotes oncogenesis through Bcl-2/Bcl-xL upregulation. Cancer Res (2009) 69, 9346-53.

Sorli SC, Colié S, Albinet V, Dubrac A, Touriol C, Guilbaud N, Bedia C, Fabriàs G, Casas J, Ségui B, Levade T, Andrieu-Abadie N. The nonlysosomal β-glucosidase GBA2 promotes endoplasmic reticulum stress and impairs tumorigenicity of human melanoma cells. FASEB J (2013) 27, 489-98.

Albinet V, Bats ML, Huwiler A, Rochaix P, Chevreau C, Ségui B, Levade T, Andrieu-Abadie N. Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. Oncogene 2013 Jul 29.

Scientific summary

 Main Research interests

Ceramide Metabolism, Melanoma, Microenvironment.

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