Marie-Christine BOUTON PhD, Thrombosis and Haemostasis, Vascular Cell Biology

Course and current status

Course and current status

2013-         : "Directeur Recherche 2ème classe" INSERM. National Institute of Health and Medical Research (INSERM U1148, www.lvts.fr), Paris, France. “Proteases and anti-proteases in vascular systems and in thrombosis and haemostasis.”

2005- 2013 : Research Scientist. (INSERM U698)

1999-2004: Research Scientist. (INSERM E9907 and E0348), Paris, France “Thrombin and vascular cells

1995-1998: Postdoctoral position. Friedrich Miescher Institute (FMI), Basel, Switzerland. “Regulation of protease nexin-1 by the renin-angiotensin system in nervous cells

1991-1994: PhD student in Cell Biology and Thrombosis and Haemostasis, University Paris VII, Denis Diderot, France.”Human thrombin specificity-Structure-functions relationships.”

Training & Research activities

Director of PhD students, Supervisor of Master students.

University teaching: Paris 7 Master ”Cell Biology, Physiology and Physiopathology”.

Board member of the French Society for Thrombosis and Haemostasis (GEHT)

Reviewer for Blood, J.Thromb.Haemost., Thromb.Haemost., ATVB...

Patent

Bouton MC et al. : Methods and pharmaceutical compositions for promoting fibrinolysis and thrombolysis.

Bouton MC et al. : Methods and pharmaceutical compositions for treatment of haemorrhagic diseases.

Scientific summary

My research focuses on the role of the proteases-antiproteases equilibrium in vascular pathologies and in tissue remodeling. I was first interested in thrombin cellular effects and now focus my projects on the regulation of thrombin and proteases of the fibrinolytic system by tissue inhibitors belonging to the serpin superfamily, with a particular interest on protease nexin-1. We have demonstrated that this serpin is an underestimated regulator in vascular biology since it has anticoagulant, antithrombotic and antifibrinolytic properties. We are now demonstrating that this serpin could play important roles in pathophysiological situations as varied as haemorrhagic diseases, inflammation, tissue remodeling, atherothrombosis or angiogenesis, by using different complementary approaches from biochemistry, molecular biology to cell biology and animal experimentation.

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