Soazig Le Lay
  • E-mail :[email]
  • Phone : +33244688413
  • Location : Angers & Nantes
Last update 2021-03-24 12:14:53.295

Soazig Le Lay Soazig Le Lay, PhD in Physiology

Course and current status

University degrees and qualifications

2012 : HDR, Univ Paris Descartes (Paris V)

2010 : Promoted Research Scientist CR1 INSERM

2006 : Recruited Junior Scientist (CR2) at INSERM

2003-2006: Marie-Curie Post doctoral Fellow at MPI-Cellular Biology and Genetics, Dresden, Germany

2003 : PhD in Physiology, Univ. Pierre and Marie Curie (Paris VI)

1999: Animal Experimentation level I, Univ Toulouse (Toulouse III)

Professionnal experiences

 

From 2021, INSERM U1087, Team IV (B Cariou), Research axis : Extracellular Vesicles (EVs) and intercellular communication in metabolic diseases (EVlink), Angers & Nantes

2012-2020, INSERM U1063 (R Andriantsitohaina), Angers, France. "Adipocytes and membrane remodeling : characterization of adipose tissue-derived extracellular vesicles" 

2006-2012, INSERM U872 - Equipe 8 (P Ferré), Research group Isabelle Dugail, Paris. "Role of caveolin proteins in lipid droplet expansion"

2003-2006 : Post Doctoral fellow : Max Planck Institute of Cellular Biology and Genetics, Pr Kai Simons, Dresden, Germany. "Lipid microdomains (so-called lipid rafts) and adipocytes"

2000-2003 : PhD student : INSERM U671 (Pascal Ferré), Paris, France. Research program: Role of SREBPs transcription factors in adipocyte metabolism

Scientific summary

I am getting interested for 20 years in molecular and cellular mechanisms regulating white adipose tissue (WAT) physiopathology and obesity-associated metabolic diseases (type II diabetes, cardiovascular diseases or non alcoholic steatohepatitis/NASH) whose occurrence has dramatically increased over the past few years.

WAT constitutes the main energy supply in the body, being mobilized according to body needs, which implies a permanent communication with other cells composing WAT as well as with other organs. In addition, adipocyte, the functionnal cell unit of WAT dedicated to lipid storage, has to face with drastic changes in cell size volume depending on hormonal and nutritionnal status.

Based on a solid background and knowledge in lipid trafficking and adipocyte cellular biology, my research focuses on adipocyte membrane remodeling processes occuring during obesity. Particularly, her project aims to test the possibility that WAT derived-extracellular vesicles (EVs), including exosomes and microvesicles, might act as a mode of intercellular communication and influence development of metabolic complications related to obesity.

Original and innovative approaches using specific proteins as EV tracers are employed to better characterize EVs in term of proteins, lipid and genetic material content. The impact of these secreted EVs on the metabolism of adipocytes, macrophages and hepatocytes constitute the heart of my studies.

EVs have appeared recently as potential powerful tools which can be viewed as diseases biomarkers and used in clinic as potential predictive factors for cardiometabolic disease development. My research theme therefore takes part of the emerging field of EVs, which deserves better characterization in the perspective to use them as therapeutic strategies to prevent or limit the development of obesity associated metabolic complications.

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