Soazig Le Lay
  • E-mail :[email]
  • Phone : +33244688581
  • Location : Angers, France
Last update 2018-10-02 15:54:31.575

Soazig Le Lay Soazig Le Lay, PhD in Physiology

Course and current status

University degrees and qualifications

2012 : HDR, Univ Paris Descartes (Paris V)

2010 : Promoted Research Scientist CR1 INSERM

2006 : Recruited Junior Scientist (CR2) at INSERM

2003-2006: Marie-Curie Post doctoral Fellow at MPI-Cellular Biology and Genetics, Dresden, Germany

2003 : PhD in Physiology, Univ. Pierre and Marie Curie (Paris VI)

1999: Animal Experimentation level I, Univ Toulouse (Toulouse III)

Professionnal experiences

Since July 2012, INSERM U1063 (Ramaroson Andriantsitohaina), Angers, France. "Adipocytes and membrane remodeling : characterization of adipose tissue-derived extrcaellular vesicles" 

2006-2012, INSERM U872 - Equipe 8 (Pascal Ferré), Research group Isabelle Dugail, Paris. "Role of caveolin proteins in lipid droplet expansion"

2003-2006 : Post Doctoral fellow : Max Planck Institute of Cellular Biology and Genetics, Pr Kai Simons, Dresden, Germany. "Lipid microdomains (so-called lipid rafts) and adipocytes"

2000-2003 : PhD student : INSERM U671 (Pascal Ferré), Paris, France. Research program: Role of SREBPs transcription factors in adipocyte metabolism

Scientific summary

I have been interested for more than 10 years in molecular and cellular mechanisms regulating white adipose tissue (WAT) physiopathology and obesity-associated metabolic diseases (type II diabetes or cardiovascular diseases) whose occurrence has increased dramatically over the past few years.

WAT constitutes the main energy supply in the body, being mobilized according to body needs, which implies a permanent communication with other cells composing WAT as well as others organs. In addition, adipocyte, the functionnal cell unit of WAT dedicated to lipid storage, has to face with drastic changes in cell size volume depending on hormonal and nutritionnal status.

Based on a solid background and knowledge in lipid trafficking and adipocyte cellular biology, my focus concerns adipocyte membrane remodeling processes occuring during obesity. Particularly, my research project aims to test the possibility that adipose tissue derived-extracellular vesicles (EVs), including exosomes and microvesicles, might act as a mode of intercellular communication and influence development of metabolic complications related to obesity.Original and innovative approaches using specific proteins as EV tracers are employed to better characterize WAT-derived EVs in term of proteins, lipid and genetic material content. The impact of these secreted EVs on the metabolism of adipocytes, macrophages and endothelial cells constitute the heart of our studies.

EVs have appeared recently as potential powerful tools which can be viewed as diseases biomarkers and used in clinic as potential predictive factors for cardiometabolic disease development. My research theme therefore takes part of the emerging field of EVs, which deserves better characterization in the perspective to use them as therapeutic strategies to prevent or limit the development of obesity associated metabolic complications.

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