• E-mail :[email]
  • Phone : 02 35 14 66 26
  • Location : Mont-Saint-Aignan, France
Last update 2012-09-14 17:40:37.191

Isabelle LIHRMANN-BISSON PhD Cell Biology

Course and current status

CURRENT POSITION : Researcher at the INSERM Institute since 1989, Team 'Functional Genomics and Neuronal and Neuroendocrinre Physiopathology'(Head Y. Anouar) at INSERM U982, University of Rouen, IRIB Haute-Normandie, France


I made my whole career in the field of neuroendocrinology, more specifically focusing on neuropeptidergic communication. My Ph.D. in Cellular and Molecular Biology was obtained in 1986 in the Laboratory of Molecular Endocrinology (CNRS URA 650, Head H. Vaudry, Rouen). I analyzed the role of calcium and prostaglandins in the signalling pathways activated by ACTH and AII and I got solid basis in cell biology. Then I obtained a postdoctoral position in the Laboratory of Molecular Genetics of Eukaryotes co-directed by Jacques Drouin and Mona Nemer in Montreal (1986-88). I contributed to decipher the transcriptional mechanisms that dictate the cardiac specific expression of the ANF gene. During these two years I acquire a good expertise in molecular bilology. Then I obtained a permanent position as chargée de Recherche (CR) at INSERM in 1989. My main project was to identify new neuropeptides using comparativbe genomics and molecular biology. My main result was the charcterization of the urotensin II gene in mammals.

  • 1982-1986 - PhD student in Molecular and Cellular Biology in the laboratory of Molecular Endocrinology (URA CNRS 650, Head H. Vaudry). Role of calcium in stimulus-secretion coupling.
  • 1986-1988 - Post-doctoral position in the Laboratory of Molecular Genetics of Eukaryotes, Clinical Research Institute of Montreal, Canada (Head J. Drouin and M. Nemer). Characterization of cis-activating sequences involved in the cardiac transcriptional regulation of the atrial natriuretic factor (ANF) gene
  • 1988-1989 - Post-doctoral position, Department of Animal Physiology, Nijmegen, Holland (Direction : G. Martens) Cloning of the cDNA encoding frog POMC
  • - Permanent position et INSERM as Chargée de Recherches

Teaching - Masters 1 and 2 “Biologie-Santé”, Neurosciences

PhD supervision - 5 PhD, past and present

 Evaluation committees

  • Member of the Expert Committee (66-69th sections) of the University of Rouen, (2009-2012)
  • Member of the Expert Committee 64th section) of the University Paris V (2009)
  • Member of Inserm Scientific Committee N°6 (CSS 6), Neuroscience, Cognition, Mental Health (2012-2016)
  • Member of French Society of Neuroendocrinology
  • Member of the Management Committee of the Unit 982 Inserm
  • Reviewer for Journals
  • Editorial member of Métabolisme, Hormones, Diabères, Nutrition (MHDN) since 2003





Scientific summary

Our main objective is to characterize new pathways involved in the processes of neurodevelopment and neuroprotection in order to propose new therapeutic targets. We have found previously that the neuropeptide PACAP exerts its powerful neuroprotective effects via the overexpression of a specific thiorodexin-like protein called selenoprotein T (SelT), the structure of which is evocative of an antioxidant protein acting as ROS scavenger. We currently characterize this new antioxidant system using molecular biology in combination with biochemistry. A number of conditional transgenic knock out mice developed in the laboratory are used, as well as mouse models of neurodegenerative diseases. We analyze the spatial and temporal expression of the SelT antioxidant system. We characterize SelT upstream and downstream effectors which may constitute with SelT new putative therapeutic targets. The biological role of native SelT is explored in vitro in cultured cell lines originating from neuroblastoma and pheochromocytoma. In parallel we perform structure-activity studies in order to design powerful neuroprotective tools. This research project is supported a number grants (SEINARI, Région Haute Normandie, Trans Channel Neurosciences Network).

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