ATIP-Avenir group Leader, Department of Neurobiology, IGF Montpellier, Inserm U 661
Research Associate 1st class, Inserm
2007-10 Visiting Scientist, Department of Neuroscience, Karolinska Institutet, Stockholm (Pr. G. Fisone).
2005-09 Research Associate 2nd class, Inserm U536
2001-04 Post-Doctoral Fellow, Inserm U536 (Dr. J.A. Girault)
1998-01 Graduate Student, Department of Neuropsychopharmacology, University Pompeu Fabra, Barcelona (Pr. R. Maldonado) and CNRS, University Paris VI (Dr. J. Caboche).
1997-98 Pregraduate Student, Inserm U266 (Pr. B.P. Roques)
2001 PhD in Neurosciences (University Paris VI and University Pompeu Fabra, Barcelona)
1998 Master in Neurosciences (University Paris VI)
2009 ATiP-Avenir grant
Selection and execution of appropriate behavioral responses rely on the ability to properly use sensory information to predict future rewards or punishments. The dorsal striatum and the nucleus accumbens are two major structures critically involved in this learning process. We put forward that the regulation of local mRNA translation control, resulting from the integration of glutamate-mediated sensory information and dopamine-mediated reward signals, could be an important process that elicits the neuronal plasticity required for striatal-dependent learning. The general objective of our research aims to characterize the molecular mechanisms involved mRNA translational control resulting from the integration of dopamine and glutamate signals and to understand the functional impact of such events on dopamine-controlled learning and pathology. Beyond its implication in basic science, our project may also provides important information for the development of new therapeutic strategies in neurological and psychiatric disorders related to striatal dysfunction such as Parkinson’s disease, obsessive-compulsive disorder and drug addiction.