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  • Location : Paris, France
Last update 2020-05-08 00:20:54.578

Angélique Levoye Associate Professor

Course and current status

Sept 2016 : Associate Professor, INSERM U970  « Regenerative Therapies For Cardiac And Vascular Diseases » - Paris Cardiovascular Research Center (PARCC) 

2011-16: Associate Professor, « INSERM-University Chair position » INSERM U1148  « Laboratory of Vascular Translational Science» - Paris 13 University

 2010-11 : Research assistant in F. Arenzana-Seisdedos ’s laboratory at the Pasteur Institute, Paris, France

2006-09 : Post-doctoral fellow in F. Bachelerie‘s team at the Pasteur Institute, Paris, France

2002-05 : PhD in molecular pharmacology in R. Jockers ’s team at the Cochin Institute, Paris, France (Paris 11 University)

• 2001-02 : Master degree in cell biology at the Lille 1 University, France

Scientific summary

I obtained my PhD in Biochemistry and Molecular Biology from Paris Sud 11 University in 2005. During my PhD in Ralf Jocker’s Team at Cochin Institute in Paris, my work consisted to investigating the functional consequences of melatonin receptors heterodimerization and to searching the function of orphan G-Protein Coupled Receptor (GPCR) GPR50. 

In 2006, I jointed the Françoise Bachelerie’s Team at Pasteur Institute in Paris as post-doctoral fellow. During this period, I’m interested to the interactions between the chemokine CXCL12/SDF-1 and it’s receptors CXCR4 and ACKR3/CXCR7 in a physiological and pathological context (WHIM syndrome, HIV infection). I have also investigated the contribution of ACKR3/CXCR7 in biological activities of CXCL12. I showed that ACKR3/CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling. 

Since 2011, I have a permanent position as associate professor at the University Sorbonne Paris Nord. I worked at INSERM U1148 (Laboratory of Vascular Translational Science) at Bichat hospital in Paris where I investigated the role of High Density Lipids (HDL) receptors in vasculo-protective effects of HDL on Blood-Brain Barrier in ischemic sroke.

Since 2016, I work in the Jean-Sebastien Silvestre ’s Team at Paris Cardiovascular Research Center (PARCC / Georges Pompidou European Hospital), and I interested to the role of chemokine CXCL12 and ACKR3/CXCR7 receptor in post-ischemic remodeling and cardiac regeneration after myocardial infarction by combining genetic approaches in the mouse with a wide range of cell and molecular biology methods.

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