Gervaise Loirand
  • E-mail :[email]
  • Phone : +33 2 28 08 01 16
  • Location : Nantes, France
Last update 2014-12-10 16:54:52.417

Gervaise Loirand PhD, Vascular Biology

Course and current status

Titles and Certifications
  • 1985   DEA, University of Bordeaux II
  • 1988   PhD, University of Bordeaux II
  • 2001   HDR, University of Nantes

Career Development
  • 1985-1988: PhD, University of Bordeaux II
  • 1988-1991:  Research engineer CNES, INSERM CJF 88-13, Bordeaux
  • 1991-1995:  Researcher -CR2 Inserm, INSERM CJF 88-13, Bordeaux
  • 1995-1998:  Researcher-CR1 Inserm - IPMC, UPR CNRS 411 (Pr. Lazdunski), Nice/Sophia-Antipolis
  • 1998-2002: CR1 Inserm - INSERM U-533 (Pr. D. Escande), Nantes.
  • Since 2002:  DR2 Inserm - Research manager - INSERM U-533, then U-915, Nantes
  • Since 2011:  DR1 Inserm - Research manager - INSERM UMR_S1087Nantes

Scientific summary

Biosketch
Gervaise Loirand (PhD) is leading the team “Signalling and hypertension” of Inserm Unit 1087, Nantes, France. She has a strong expertise in the molecular mechanisms and intracellular signalling pathways regulating smooth muscle cell contractility and arterial tone. She authored or co-authored ~95 articles in peer-reviewed journals. GL is recognized as a key player in the discovery of the role of Rho proteins in the pathogenesis of vascular diseases. With her team, she has recently identified the molecular mechanisms coupling AT1 receptors to RhoA activation and RhoA dependent functions in vascular smooth muscle cells.
Loirand G, Sauzeau V, Pacaud P, Physiol Rev, 2013;93:1659-1720
Loirand G, Pacaud P. Nat Rev Cardiol, 2010, (11):637-47
Guilluy C et al., , Nat Med, 2010; 16(2):183-90
Guilluy C, et al. Circ Res, 2008 ; 102(10):1265-74

Major contribution in vascular biology and pathophysiology
  • Discovery of L-type calcium channel in vascular smooth muscle cells 
  • Demonstration of the major role of the vascular endothelium in the control of RhoA/Rho kinase signaling pathway in arterial smooth muscle cells
  • Identification of RhoA/Rho kinase activation and molecular mechanisms responsible for this activation in systemic and pulmonary arterial hypertension
  • Discovery of the essential role of the RhoA exchange factor Arhgef1 in Angiotensin II-induced vascoconstrction and hypertension
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