1998-2002: CR1 Inserm - INSERM U-533 (Pr. D. Escande), Nantes.
Since 2002: DR2 Inserm - Research manager - INSERM U-533, then U-915, Nantes
Since 2011: DR1 Inserm - Research manager - INSERM UMR_S1087Nantes
BiosketchGervaise Loirand (PhD) is leading the team “Signalling and hypertension” of Inserm Unit 1087, Nantes, France. She has a strong expertise in the molecular mechanisms and intracellular signalling pathways regulating smooth muscle cell contractility and arterial tone. She authored or co-authored ~95 articles in peer-reviewed journals. GL is recognized as a key player in the discovery of the role of Rho proteins in the pathogenesis of vascular diseases. With her team, she has recently identified the molecular mechanisms coupling AT1 receptors to RhoA activation and RhoA dependent functions in vascular smooth muscle cells.Loirand G, Sauzeau V, Pacaud P, Physiol Rev, 2013;93:1659-1720Loirand G, Pacaud P. Nat Rev Cardiol, 2010, (11):637-47Guilluy C et al., , Nat Med, 2010; 16(2):183-90Guilluy C, et al. Circ Res, 2008 ; 102(10):1265-74 Major contribution in vascular biology and pathophysiology
Discovery of L-type calcium channel in vascular smooth muscle cells
Demonstration of the major role of the vascular endothelium in the control of RhoA/Rho kinase signaling pathway in arterial smooth muscle cells
Identification of RhoA/Rho kinase activation and molecular mechanisms responsible for this activation in systemic and pulmonary arterial hypertension
Discovery of the essential role of the RhoA exchange factor Arhgef1 in Angiotensin II-induced vascoconstrction and hypertension