Didier Pinault
  • E-mail :[email]
  • Phone : 0368853245
  • Location : Strasbourg, France
Last update 2012-01-16 15:28:32.166

Didier Pinault PhD Neurosciences

Course and current status

Academic essentials

  • 1974: Bachelor in Biological Sciences, Lycée Technique d’Etat, Bourges, France.
  • 1990: PhD in Neuroscience, Université Pierre et Marie Curie, Paris 6, France.
  • 2001: Accreditation to supervise research, Université Louis Pasteur, Université de Strasbourg, France.
  • 1997-: Invited reviewer for peer-reviewed Journals.
  • 2002-: Invited reviewer for national and international funding organizations.
  • 2009-: Guest Editor of European Journal of Neuroscience.
  • 2011-: Review Editor of Frontiers in Schizophrenia.
  • 2010-: Member of the GDR multi-électrodes; Member du club de Modulation Cérébrale de l’AFPB.
  • 2010-: Faculty Member of the Trinational Joint Master in Neuroscience (Basel, Freiburg, Strasbourg).
  • 2011-: Review Editor of Frontiers in Schizophrenia.
  • Other: Member of the American, European and French Societies of Neuroscience.


  • 1975-83: Engineer, electro-neuropharmacology, Delalande Laboratories, Rueil-Malmaison, France.
  • 1984-90: Thesis in Neurosciences, INSERM U97, Université P & M Curie, Paris 6, France.
  • 1990-92: Postdoc Res, Laval University, Québec, neurophysiology of thalamocortical systems.
  • 1992-97: Res Ass, Laval University, Québec, neurophysiology of thalamocortical systems.
  • 1997-2002: Engineer, Inserm U398, Univ L Pasteur, Université de Strasbourg, pathophysiology of cortex-thalamus systems.
  • 2002-2007: Engineer, Inserm U405 then U666, Université de Strasbourg, dynamics and pathophysiology of cortex-thalamus systems.
  • 2007-: CR1, A/Prof, Inserm U666, Université de Strasbourg, Pathophysiology and Neuromodulation of Cortex-Thalamus Systems.


Major discoveries

  • 1985-1990: New functional integration concept: Axon terminals integrate local environmental signals and generate backpropagating action potentials. Thesis work: Brain Res Rev, 1995.
  • 1991-1996: Make visible the invisible: The juxtacellular technique to reveal the morphofunctional properties of single neurons. J Neurosci Methods, 1996.
  • 1995-1998: The first anatomical demonstration of the principle of lateral inhibition in the thalamus. Eur J Neurosci, 1998.
  • 1997-2005: A new cell-to-network pathophysiological concept in epilepsy: Layer VI corticothalamic neurons initiate spike-and-wave discharges in genetically determined absence seizures. J Physiol, 2003.
  • 1997-2005: State-of-the-art micro-neurosurgery for cell-to-network electrophysiological approaches: A micro-cranioduratomy, state-of-the-art technique to explore the structure and function of living intact neurons and networks. J Neurosci Methods, 2005.
  • 2002-: Toward a new cell-to-network pathophysiological concept in schizophrenia: Electrophysiological signature in a new model for pathogenesis of psychoses. Biol Psychiatry, 2008.
  • 2009-: Toward a preclinical neurophysiological cell-to-network therapeutic concept. Dysfunctional thalamus-related networks in schizophrenia, Schizophr Bull, 2010.

Recent/current fellows:

  • 2004-06: Andrea Slézia, Inst Exp Med, Budapest, Hungary. Marie-Curie Research Training Progam.
  • 2006-07: Terence J O’Brien, Prof, University of Melbourne, Australia. Sabbatical.
  • 2007-10: Thomas Zheng, PhD student, Univ of Strasbourg & Melbourne. Bourse d’excellence Eiffel Doctorat.
  • 2008: Julien Gaudias, M2 student, Univ of Strasbourg.
  • 2008: Elena A Tolmacheva, Inserm postdoctoral researcher.
  • 2009: Joseph Chaumont, M2 student, Univ of Strasbourg.
  • 2009-: Sofya Kulikova, Trinational Joint Master in Neuroscience (univ of Strasbourg, Freiburg and Basel).
  • 2010-11: Brendan E Adams, Neurex-UdS postdoctoral researcher.
  • 2010-11: Anne-Sophie Bouillot, Licence Pro physiopathologie/pharmacologie (Univ Joseph Fourier, Grenoble).
  • 2010-: Paul Anderson, co-tutelle PhD student of Univ of Strasbourg & Melbourne.


  • LMD Université de Strasbourg and European Neurex Network;
  • Research training from & for Biomedical Research;
  • Electrophysiology School of Strasbourg.

Selection of Invited Conferences, Workshops, Symposia, etc.:

  • 2003, Basel: Trinational Neurex Workshop on Cerebral Rhythms.
  • 2003, Strasbourg: Colloque Imagerie et Photonique pour les Sciences du Vivant et la Médecine (IMVIE).
  • 2005, Göttingen: German Symposium on neuronal activity, synaptic transmission and network dynamics.
  • 2006, Vienne: European FENS Technical Workshop on Noninvasive High Resolution Recording Techniques.
  • 2007, Antalya: CEA-ILAE Symposium on Idiopathic Generalized Epilepsies.
  • 2008, Nurnberg: 2nd World Conference on Magic Bullets on Psychoactive drugs.
  • 2008, Rouffach: IPEG Symposium on EEG and NMDAr antagonists.
  • 2008, Seattle: AES Workshop on Cortical focus of Absence Seizures.
  • 2009, Strasbourg: 8eme Journée Pierre Deniker.
  • 2009, Paris: 9th World Congress of Biological Psychiatry on Psychotic disorders.
  • 2010, Strasbourg: International Neurex Workshop on Deep Brain Stimulation.
  • 2010, Aix: Journée Neurosciences: avancées, partenariats et médicaments de demain.
  • 2010, Boppard: Swiss-German Symposium on Barrel Cortex Function (BaCoFun).
  • 2011, Freiburg: International Neurex Berstein Conference on Basal Ganglia and Deep Brain Stimulation.
  • 2011, Berlin: DGPPN, Berlin Psychiatry Congress, Neural Oscillations in Schizophrenia.
  • 2012, Heidelberg: Berstein R&D Workshop Cellular Electrophysiology.


Scientific summary

A modern approach of the mind-brain problem:

My research falls into the interface of molecular biology and clinical research. Models are used to understand pathophysiological mechanisms of CNS illnesses and to develop neurophysiological therapeutic concepts. Corticothalamic and thalamocortical systems are the neuronal substrates that are essential to consciousness and cognition. They operate according to a oscillatory mode during thought and action. We develop and refine neurosurgical and electrophysiological multiple-scale approaches to explore and modulate their spatiotemporal dynamics and neurophysiological properties during neural interactions, oscillations and synchronizations. Understanding function/dysfunction of complex neural systems with modern cell-to-network approaches of the mind-brain problem will improve our quality of life.

DP, January 14, 2012

Image d’exemple