Guillaume Pidoux PhD Physiology and development

Course and current status

Education/Training: Habilitation, University Paris V (2013); Ph.D. in physiology and development (2006), Paris VII University; M.Sc. in physiology and development (2002), University Paris VIII.

 

Positions and Employment: 2016-Present: CR1, Inserm UMR-S1180; 2015-2016: CR2, Inserm UMR-S1180; 2012-2015: CR2, Inserm, UMR-S-1139; 2010-2012: postdoc fellow at UMR-S-767, University Paris V, Paris; 2007-2010: Post-Doc Fellow at the Nordic EMBL & BiO, University of Oslo, Norway; 2002-2006: PhD Thesis with distinction at Inserm U427, University Paris VII, Paris.

 

Other scientific and administrative activities: Scientific direction of 1 Postdoc, 1 Engineer Inserm, 1 technician Inserm, 4 Masters and 3 BTS, DUT; 2012: Filled a patent (DOFI no. 12043: “Method to regulate the opening of connexin-43 junctions”); 2011: Initiator and co-manager of the French cAMP network (with Dr. P. Vincent); Elected by European Placenta Group Business Meeting as the EPG Planning Committee.

 

Awards, Grants and distinctions: 2013: Grant for young investigator Inserm (40 k€) 2012: Gordon Research Conference, best short oral presentation; SFBBM publication award of March; 2011: Yggdrasil project (18 k€); 2010: SFBBM travel funding for 35th FEBS congress; FEBS youth travel fund for the workshop on spatiotemporal dynamics of cell signaling.

 

Five Recent publications:

  1. Gerbaud P., Taskén K., & Pidoux G. Spatiotemporal regulation of cAMP signaling controls the human trophoblast fusion. Front Pharmacol. 2015 Sep 15;6:202. doi: 10.3389/fphar.2015.00202. 
  2. Pidoux G., Gerbaud P., Guibourdenche J., Therond P., Ferreira F., Simasotchi C., Evain-Brion S., & Gil S. Formaldehyde crosses the human placenta and affects human trophoblast differentiation and hormonal functions. PLoS ONE.2015 Jul 17;10(7):e0133506.
  3. Pidoux G., Gerbaud P., Dompierre J., Lygren B., Solstad T., Evain-Brion D., & Taskén K. A PKA-ezrin-connexin 43 signaling complex controls gap junction communication leading to trophoblast cell fusion. J Cell Sci. 2014. 127: 4172-4185.
  4. Pidoux G., Witczak O., Jarnæss E., Myrvold L., Urlaub H., Stokka AJ., & Taskén K. Optic Atrophy 1 is an A-kinase anchoring protein that mediates adrenergic control of lipolysis. EMBO J. 2011, 30: 4371-86. doi: 10.1038/emboj.2011.365.
  5. Pidoux G., Gerbaud P., Guibourdenche J., Pathirage N., Costa JM., Badet J., Frendo JL., Murthi P., & Evain-Brion D. Mesenchymal Activin-A Overcomes Defective Human Trisomy 21 Trophoblast Fusion. Endocrinology. 2011, 152 :5017-28.
  6. Pidoux G., Gerbaud P., Gnidehou S., Grynberg M., Cronier L., Guibourdenche J., Ferreira F., Badet J., Malassiné A., Evain-Brion D., & Frendo J-L. ZO-1 is required for trophoblastic cell-cell fusion in human placenta. Am J Physiol Cell Ph. 2010, 298: 1517-26.

Scientific summary

Cell fusion processes are complex biological phenomena essential in fertilization, fetal development, skeletal muscle formation, bone homeostasis and metastatic process. Cell fusion and syncytial formation result in the mixing of plasma membrane components and merging of cell content between two or more cells. For many years now, my group are interested in the spatiotemporal regulation of the cAMP signaling controling the cell fusion process in various models (i.e. human placenta and cancer cells). We mainly focuses on understanding the direct role of A-Kinase Anchoring Proteins (AKAPs) and phosphodiesterases (PDEs) in cell fusion processes. The group 'Cell Fusion' experienced molecular mechanisms underlying cell-fusion for more than 10 years now.

Image d’exemple