Natacha Rochel
  • E-mail :[email]
  • Phone : 333.69.48.52.93
  • Location : Strasbourg, France
Last update 2014-10-24 21:57:51.145

Natacha Rochel PhD

Course and current status

Diplomas

•1993: PhD in Physical Chemistry, University Louis Pasteur, Strasbourg, under the supervision of Dr. Anne-Marie Albrecht-Gary.

 « Mécanismes de transport du fer : Etudes physico-chimiques de sidérophores naturels et de ligands biomimétiques » - EHICS Strasbourg France.

•2009: Habilitation to supervise research (HDR), University Louis Pasteur, Strasbourg, France.

 "Structure of nuclear hormone receptors."

Faculty positions

°2014-present: CNRS research director (DR2) IGBMC

•1998: CNRS senior scientist (CR1) in the Department of Integrative Structural Biology of IGBMC, Strasbourg, France.

•1994, 1996-1998: Postdoctoral associate in the laboratory of Dr Dino Moras at IGBMC, Strasbourg, France.

“ Structural studies of nuclear receptors ligand binding domain.”

•1995: Postdoctoral fellow  in the laboratory of Pr James Cowan, Ohio State University, Columbus, OH, USA. Lavoisier grant fellow.

Mechanism of lytic activity of the amino-terminal domain of human perforin.”

Scientific summary

Research project: Structure of nuclear hormone receptors.

N. Rochel has joined the IGBMC Integrative Structural Biology Department in 1996. Her research project is aiming at the functional and structural studies of human nuclear hormone receptors and associated proteins. These multi-protein complexes are involved in transcription and its regulation. Our goal is to understand the mechanisms that control gene expression through integrative structural biology approaches in order to obtain information from the atomic to the cellular scale, using biophysical characterization techniques, structural studies in solution, cryo-electron microscopy and crystallography. The results of our research will provide more efficient molecular tools allowing precise control over cell programming and reprogramming and will have immediate impact in therapeutic applications. The experiments are done in the Integrative Structural Biology Department of IGBMC using state-of the-art methods developed in the frame the European Integrated Structural Biology Infrastructure (INSTRUCT ) and its National counterpart the French Infrastructure for Integrated Structural Biology (FRISBI).

 

Project members

 Natacha Rochel (coordinator)

Carole Peluso-Iltis, research engineer

Anna Belorusova, PhD student

Judit Osz, post-doctoral associate

Rita Sigüero, post-doctoral associate

 

Former members

 Tiphaine Huet, PhD student

Serena Sirigu, PhD student

Sabrina Kammerer, PhD student

Fabrice Ciesielski, PhD student

Pierre Antony, post-doctoral associate

Yann Belivet, post-doctoral associate

Shinji Hourai, post-doctoral associate

Ferdinand Molnar, post-doctoral associate

Edelmiro Moman, post-doctoral associate

Nick Ramalanjaona, post-doctoral associate

Yoshiteru Sato, post-doctoral associate

Giuseppe Tochhini-Valentini, post-doctoral associate

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