•1993: PhD in Physical Chemistry, University Louis Pasteur, Strasbourg, under the supervision of Dr. Anne-Marie Albrecht-Gary.
« Mécanismes de transport du fer : Etudes physico-chimiques de sidérophores naturels et de ligands biomimétiques » - EHICS Strasbourg France.
•2009: Habilitation to supervise research (HDR), University Louis Pasteur, Strasbourg, France.
"Structure of nuclear hormone receptors."
°2014-present: CNRS research director (DR2) IGBMC
•1998: CNRS senior scientist (CR1) in the Department of Integrative Structural Biology of IGBMC, Strasbourg, France.
•1994, 1996-1998: Postdoctoral associate in the laboratory of Dr Dino Moras at IGBMC, Strasbourg, France.
“ Structural studies of nuclear receptors ligand binding domain.”
•1995: Postdoctoral fellow in the laboratory of Pr James Cowan, Ohio State University, Columbus, OH, USA. Lavoisier grant fellow.
“Mechanism of lytic activity of the amino-terminal domain of human perforin.”
Research project: Structure of nuclear hormone receptors.
N. Rochel has joined the IGBMC Integrative Structural Biology Department in 1996. Her research project is aiming at the functional and structural studies of human nuclear hormone receptors and associated proteins. These multi-protein complexes are involved in transcription and its regulation. Our goal is to understand the mechanisms that control gene expression through integrative structural biology approaches in order to obtain information from the atomic to the cellular scale, using biophysical characterization techniques, structural studies in solution, cryo-electron microscopy and crystallography. The results of our research will provide more efficient molecular tools allowing precise control over cell programming and reprogramming and will have immediate impact in therapeutic applications. The experiments are done in the Integrative Structural Biology Department of IGBMC using state-of the-art methods developed in the frame the European Integrated Structural Biology Infrastructure (INSTRUCT ) and its National counterpart the French Infrastructure for Integrated Structural Biology (FRISBI).
Natacha Rochel (coordinator)
Carole Peluso-Iltis, research engineer
Anna Belorusova, PhD student
Judit Osz, post-doctoral associate
Rita Sigüero, post-doctoral associate
Tiphaine Huet, PhD student
Serena Sirigu, PhD student
Sabrina Kammerer, PhD student
Fabrice Ciesielski, PhD student
Pierre Antony, post-doctoral associate
Yann Belivet, post-doctoral associate
Shinji Hourai, post-doctoral associate
Ferdinand Molnar, post-doctoral associate
Edelmiro Moman, post-doctoral associate
Nick Ramalanjaona, post-doctoral associate
Yoshiteru Sato, post-doctoral associate
Giuseppe Tochhini-Valentini, post-doctoral associate