Course and current status
Jean-Pierre Mothet is a former PhD student of Doctor Ladislav Tauc in Gif-sur-Yvette. He received his MSc in Physiology at the University of Lyon in 1992 and then his PhD in Neuroscience from the University Pierre and Marie Curie, Paris, in 1996. After his Ph.D, he moved to the USA to carry out postdoctoral research in the laboratory of Professor Solomon H. Snyder at The Johns Hopkins School of Medicine in Baltimore. There he worked at deciphering the functions and the synthesis pathway of brain D-amino acids with a special focus on D-serine. He discovered serine racemase the enzyme that synthesizes D-serine and that D-serine rather than glycine is the endogenous coagonist of synaptic N-Methyl D-Aspartate subtype of glutamatergic receptors in the hippocampus. In 1999, he took a second postdoctoral position in the laboratory of Professor Jacopo Meldolesi in Milano, Italy, in the Department of Neuroscience at Vita-Salute San Raffaele University where he worked on the molecular mechanisms of regulated and constitutive exocytosis. In 2000, he took his first research appointement at the French National Center for Research (CNRS) in the laboratory of Dr. Maurice Israel then of Gérard Baux at the Institute of Neurobiology Alfred Fessard in Gif-sur-Yvette, and in 2006, he moved to Bordeaux at the Neurocentre Magendie. In 2011, he was appointed as the leader of 'Gliotransmission and Synaptopathies' team at the Centre de Recherches en Neurobiologie et Neurophysiologie de Marseille. In 2012, he was elected President of the French Club of Glial Cells. He is the member of the Editorial board of Frontiers in Synaptic Neuroscience and of PlosONE.
Positions and Employment
Honors and Awards
We are exploring the role of the atypical brain messenger D-serine and other D-amino acids in the normal and pathological nervous system using an unique and multiscale analysis. We combine biochemistry, cell biology, analytical chemistry together with cellular electrophysiology and live cell imaging to uncover the molecular and cellular cascade of events driving gliotransmission (ie the way glial cells release neuroinformative molecules) and study its functional relevance in patterning synapses and neuronal network activities in the prefrontal cortex, the hippocampus and in the enteric nervous system. We aim at advancing frontiers on the functions of brain D-amino acids and glia in the physiopathology of synapses with strong efforts to translate bench work to brain therapy and with the goal of developping novel technologies.