Scientific topics
Keywords
ITMO
Laurent SUSINI PhD
Course and current status
Lead Clinical Trial Leader March 2015 to present
Translational Clinical Oncology (TCO), Novartis
Program Clinical Trial Leader May 2014 to March 2015
Translational Clinical Oncology (TCO), Novartis
Oncology Translational Medicine (OTM), Novartis
Lead Clinical Trial Leader January 2014 to May 2014
Oncology Translational Medicine (OTM), Novartis
Clinical Trial Leader in Oncology September 2011 to December 2013
Oncology Translational Medicine (OTM), Novartis
Clinical Project Manager in Oncology January 2009 to September2011
Quintiles, Paris, France
Clinical Research Associate in Oncology June 2007 to January 2009
Quintiles, Paris, France
Research Scientist University of Sciences of Geneva 2006-2007
Department of Cell Biology, Programmed cell death and apoptosis
Group Leader 2000-2006
Molecular Engines Laboratories (France) and Weizmann Institute of Sciences (Israel)
Project Leader in oncology research 1996-2000
GENSET Genomics Research Centre (France) and LOS ALAMOS NATIONAL LABORATORY (USA)
Researcher 1994-1996
Centre d’Etude du Polymorphisme Humain (CEPH, France) and Californian Institute of Technology (Caltech, USA)
Researcher 1991-1994
Genethon (France), Myopathy Research Laboratory
.
Scientific summary
Susini L, Besse S, Duflaut D, Lespagnol A, Beekman C, Fiucci G, Atkinson AR, Busso D, Poussin P, Marine JC, Martinou JC, Cavarelli J, Moras D, Amson R, Telerman A.
TCTP protects from apoptotic cell death by antagonizing bax function.
Cell Death Differ. 2008 Aug;15(8):1211-20
Marcel Tuynder, Giusy Fiucci, Sylvie Prieur, Alexandra Lespagnol, Anne Géant, Séverine Beaucourt, Dominique Duflaut, Stéphanie Besse, Laurent Susini, Jean Cavarelli, Dino Moras, Robert Amson, and Adam Telerman. Translationally controlled tumor protein is a target of tumor reversion
Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15364-9. (Cell Biology)
Fiucci G, Beaucourt S, Duflaut D, Lespagnol A, Stumptner-Cuvelette P, Geant A, Buchwalter G, Tuynder M, Susini L, Lassalle JM, Wasylyk C, Wasylyk B, Oren M, Amson R, Telerman A. Siah-1b is a direct transcriptional target of p53: Identification of the functional p53 responsive element in the siah-1b promoter.
Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3510-5
Fiucci G, Lespagnol A, Stumptner-Cuvelette P, Beaucourt S, Duflaut D, Susini L, Amson R, Telerman A.
Genomic organization and expression of mouse Tpt1 gene. Genomics. 2003 Jun;81(6):570-8
Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel De Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A.
The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. Proc Natl Acad Sci U S A 2003 Mar 4;100(5):2284-2289
Susini L, Tuynder M, Prieur S, Besse S, Fiucci G, Amson R, Telerman A.
Biological models and genes of tumor reversion: Cellular reprogramming through tpt1/TCTP and SIAH-1.
Proc Natl Acad Sci U S A 2002 Nov 12;99(23):14976-81.
Susini L, Passer BJ, Amzallag-Elbaz N, Juven-Gershon T, Prieur S, Privat N, Tuynder M, Gendron MC, Israel A, Amson R, Oren M, Telerman A. Siah-1 binds and regulates the function of Numb.
Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15067-72.
Amson R. B., Nemani M., Roperch J. P., Israeli D., Bougueleret L., Linares-Cruz G., Lethrosne F., Pasturaud P., Piouffre L., Susini L., Millasseau P., Guidicelli C., Bui H ., Massart C., Cazes L., Dufour F., Bruzzoni-Giovanelli H., Owadi H., Hennion C., Charpak G., Dausset J., Calvo F., Oren M., Cohen D. and Telerman A.
Isolation of ten differentially expressed cDNAs in p53 induced apoptosis: Activation of the vertebrate homologue of the Drosophila seven in absentia gene. Proc. Natl. Acad. Sci. USA 1996; 93, 3953-3957.
Susini L, Ambrose WP, Jett JH, Keller RA. DNA fragment length determinations in minutes of measurement time with 2% accuracy. Patent.
Susini L., Billault A. Les nouveaux vecteurs de clonage. Technoscope, Biofutur n°153, Février 1996
Sambucy JL, Susini L, Gervy P, Glibert F, Beaufils S, Bui H, Massart C, De Tand, Le Paslier D, Cohen D.
A YAC contig map of the human genome. Sur une nouvelle technique d'analyse du caryotype humain.
C R Acad Sci 1995 272:2638–2640.
Chumakov, I.M., Rigault, P., Le Gall, I., Bellanne-Chantelot, C., Billault, A., Soularue, P., Belova, M., Sambucy, J-L., Susini, L., Dib, C., Faure, S., Fizames, C., Gyapay, G., Millasseau, P., Nguyen, S., Muselet, D., Vignal, A., Morissette, J., Menninger, J., Lieman, J., Desai, T., Banks, A., Bray-Ward, P., Ward, D., Hudson, T., Gerety, S., Foote, S., Stein, L., Page, D.C., Lander, E.S., Weissenbach, J., Le Paslier, D. and Cohen, D. A YAC contig map of the human genome. Nature. 1995 Sep 28;377(6547 Suppl):175-297.
Bellanne-Chantelot,C., Lacroix,B., Ougen,P., Billault,A., Beaufils,S., Bertrand,S., Georges,I., Glibert,F., Gros,I., Lucotte,G., Susini,L., Codani,J.-J., Gesnouin,P., Pook,S., Vaysseix,G., LU-Kuo,J., Ried,T., Ward,D., Chumakov,I., Le Paslier,D., Barillot,I., and Cohen,D. Mapping the whole human genome by fingerprinting yeast artificial chromosomes. Cell. 1992 Sep 18;70(6):1059-68.
Conferences and Abstracts
L. Susini, M. Tuynder, S. Prieur, S. Besse, N. Privat, R. Amson and A. Telerman. Biological models and genes of tumor reversion: cellular reprogramming through inhibition of TPT1/TCTP.
Cancer Genetics & Tumor Suppressor Genes. Cold Spring Harbor, August 2002.
L. Susini, M. Tuynder, J. Richardson, L. Goodman, B. Bowen, A. Géant, M. Oren, R. Amson and A.Telerman. Characterization of biological models and molecular pathways of tumor reversion: cross-talk with programmed cell death. Conference on Programmed cell death. Cold Spring Harbor, September 2001.
L. Susini, B. Passer, N. Amzallag-Elbaz, T. Juven-Gershon, S. Prieur, N. Privat, M. Tuynder, M. Oren, R. Amson and A.Telerman. SIAH binds and regulates the function of Numb.
Conference on Programmed cell death. Cold Spring Harbor, September 2001
L. Susini, M. Tuynder, J. Richardson, L. Goodman, , A. Géant, F. Dufour, E. Mas, S. Zyto, J. Tolédano, M. Oren, S. Brenner, R. Amson and A.Telerman. Characterization of biological models and molecular pathways of tumour reversion. Annual Meeting on Oncogenes, Frederick, Maryland, USA, June 2001
R. Amson, M. Tuynder, F. Lethrosne, S. Prieur, J. P. Roperch, L. Susini, M. Oren, and A. Telerman.
Uncovering tumor suppression pathways by investigating tumor reversion.
Conference on cancer genetics & tumor suppressor genes. Cold Spring Harbor, August 2000
Patents
1- SCREENING METHOD BASED ON SIAH-NUMB INTERACTION
Publication: DE60120220T - 2007-03-29
2- Sequences involved in phenomena of tumor suppression, tumor reversion, apoptosis and/or virus resistance
and their use as medicines. Publication: US2005221303 - 2005-10-06
3- Sequences involved in phenomena of tumor suppression, tumor reversion, apoptosis and/or virus resistance
and their use as medicines. Publication: US2004241671 - 2004-12-02
4- Compositions and methods for the treatment of cancers. Publication: US2004087531 - 2004-05-06
5- COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER
Publication: WO03097835 - 2003-11-27
6- New human nucleic acid, useful for diagnosis, prognosis and treatment, e.g. of tumors, also related vectors,
transformed cell, polypeptides and antibodies. Publication: FR2822475 - 2002-09-27
