Research Scientist Inserm since 2000 (competitive secure position)
LIRIC UMR 995; Inserm/Univ. Lille/CHU Lille, Lille – France
Dpt of Pharmacology, Univ. of Washington – Seattle
HFSP competitive fellowship
Inserm U377, University of Lille, France
MRES competitive fellowship
Honors: highly recommended, Dinna-Surdin award
I completed my Ph.D. in Biology at the University of Lille in France working on the human mucin gene MUC5B. I moved on to do postdoctoral work on the catalytic subunit of Protein Kinase A at the Univ. of Washington (Seattle, USA). In 2000 I was appointed to Research Scientist at the French Institute of Health and Medical Research and joined the team EA3925 in 2009 to create the team 4 of the Inserm Unit U995 at the faculty of Medicine at the University of Lille.
My current research interests are focused on the role of mucins in vivo. I am studying mucins in cystic fibrosis (CF), Inflammatory Bowel Diseases (IBD), dry eye using mainly genetically-modified mouse models. Mucins are large and heavily O-glycosylated molecules that form long polymers. The two main mucins secreted in the lung are MUC5B and MUC5AC whereas MUC2 is the main mucin in the gut. MUC2, MUC5B and MUC5AC contain multiple copies of a highly conserved domain found more than 25 times in a secreted mucin of the fish. A better understanding of the structure and the function of this domain which seems to be able to form non covalent bonds are essential to propose a new therapeutic treatment in many diseases.
Key words: mouse transgenic, mucus, mucins, molecular and cellular biology, imaging, cystic fibrosis, inflammatory bowel diseases, microbiota, experimental infection, nutrition