Jean-Luc Desseyn, PhD PhD Biology in Health and Diseases

Course and current status

20 international peer publications in first or last author

Project Leader since 2001

Research Scientist Inserm since 2000 (competitive secure position)
LIRIC UMR 995; Inserm/Univ. Lille/CHU Lille, Lille – France

  • Certified for research on animals-level I
  • Qualification to professorship (CNU 64-Biochemistry & Molecular Biology, 2015)
  • Diploma of veterinary surgery
  • Standard use of nonparametric statistics
  • Accreditation to supervise PhD students (HDR-2008)
  • Founder Member of the Regional Animal Care Committee Approval (2002-now)
  • Management of logistics and budget
  • Daily management of a research team, including Ph.D. (biologists, biochemists) and students
  • Management of scientific research and academic education of undergraduate students
  • Acquisition of funding, via government, industry, and independent foundations (French & international)
  • Academic education of undergraduate students (Licence, Master, Mastere)
  • Academic editor for PLoS One; Editorial board of Journal of Biology and Life Science, Cell Biology and Scientific Reports
  • Webmaster

Teaching

  • Molecular Biology, L3 of genetic engineering, IUP ILIS–Univ. Lille 2
  • Transgenesis, Master of Biological and Medical Sciences, Master of Agronomy, Master Drug Design and Mastere Drug design, Univ. Lille 2
  • Lecturer for the obtention of the authorization to animal experiment (National formation) – Transgenesis, homologous recombination, mouse genetics

Post Doctoral Fellowship

Dpt of Pharmacology, Univ. of Washington – Seattle
HFSP competitive fellowship

Ph.D. Biology-Health

Inserm U377, University of Lille, France
MRES competitive fellowship
Honors: highly recommended, Dinna-Surdin award

Areas of interest

  • Cystic fibrosis / Inflammatory bowel diseases / Lung disease / Gut microbiota
  • Mucus / Mucins / Glycobiology
  • Mouse transgenic / Large transgenic animals
  • Molecular Biology / Live imaging

Scientific summary

I completed my Ph.D. in Biology at the University of Lille in France working on the human mucin gene MUC5B. I moved on to do postdoctoral work on the catalytic subunit of Protein Kinase A at the Univ. of Washington (Seattle, USA). In 2000 I was appointed to Research Scientist at the French Institute of Health and Medical Research and joined the team EA3925 in 2009 to create the team 4 of the Inserm Unit U995 at the faculty of Medicine at the University of Lille.

My current research interests are focused on the role of mucins in vivo. I am studying mucins in cystic fibrosis (CF), Inflammatory Bowel Diseases (IBD), dry eye using mainly genetically-modified mouse models. Mucins are large and heavily O-glycosylated molecules that form long polymers. The two main mucins secreted in the lung are MUC5B and MUC5AC whereas MUC2 is the main mucin in the gut. MUC2, MUC5B and MUC5AC contain multiple copies of a highly conserved domain found more than 25 times in a secreted mucin of the fish. A better understanding of the structure and the function of this domain which seems to be able to form non covalent bonds are essential to propose a new therapeutic treatment in many diseases.

Key words: mouse transgenic, mucus, mucins, molecular and cellular biology, imaging, cystic fibrosis, inflammatory bowel diseases, microbiota, experimental infection, nutrition

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