Marie-Cecile Michallet
  • E-mail :[email]
  • Phone : 0478782964
  • Location : Lyon, France
Last update 2014-12-31 14:48:14.622

Marie-Cecile Michallet CR1 CNRS scientist

Course and current status

I am an immunologist. I started my carreer in 1999 in Pr J.P. Revillard's lab (Ecole Normale Supérieure de Lyon, France) working on high dose tolerance mechanisms. I focused my PhD work on understanding the mechanisms of action of molecules such as anti-CD3 antibodies and Thymoglobulin, an immunosuppressive drug widely used in the conditioning of solid organ and hematopoietic stem cell transplantation. After my PhD defense in december 2003, I moved to Pr J. Tschopp's lab (Biochemistry department, Lausanne, Switzerland) as an EMBO post-doctoral fellow. I worked on the role of the TRADD protein in innate immune responses and demonstrated that TRADD  plays an important role in RIG-like helicases, TLR-3 and TLR-4 signaling pathways. I went back in France in 2009 and got a position as CR1 CNRS in Dr J. Marvel's lab (CIRI, Centre International de Recherche en Infectiologie, Lyon)in  2010. I worked on the role of pattern recognition receptors (PRRs) in immunosurveillance process, and the impact of microbiota on inflammatory responses mediated by PRRs. Since september 2014, I am PI in the team of C Caux/JY Blay at the CRCL (Cancer Research Center of Lyon)/Centre Léon Bérard - Lyon, to pursue my investigations on the role of PRRs in immunosurveillance processes.

Scientific summary

Breast cancer (BC) is the top cancer in women both in the developed and the developing world.  To avoid developing cancer, early oncogenic insults induce intrinsic defence mechanisms such as cell-death as well as senescence, and extrinsic pathways that mobilize immune responses. However, research on intrinsic and extrinsic immune sensing of early oncogenic transformation remains limited. Pathogen recognition receptors (PRRs) sense motifs released by damaged host cells and induce potent immune responses.  We have data suggesting that PRRs expressed on pre-malignant cells as well as innate dendritic cells (DCs) detect oncogenic motifs and activate protective immunity. Using BC patient cohorts, animal approaches and in vitro models of oncogenic stress we will address: 1- the intrinsic mechanisms by which PRRs in the pre-malignant cell can detect early transformation; 2- the role of PRR in extrinsic mechanism of immune detection early stages cellular transformation by DCs present in the tumormicroenvironment. Full elucidation of the immune responses required to destroy pre-malignant mammary cells will no doubt impact the development of new therapeutic approaches in BC. 

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