• E-mail :[email]
  • Phone : +33 5 47304204
  • Location : Bordeaux, France
Last update 2019-03-05 15:08:09.609

Cécilia SAMIERI PhD Epidemiology

Course and current status

     After a doctorate in veterinary medicine, I hold a PhD in epidemiology from University of Bordeaux (France) in 2009. I completed a post-doctoral fellowship at the Channing Division of Network Medicine, Harvard Medical school (Boston, USA). Then, I returned to France with a young investigator grant awarded by the Fondation Plan Alzheimer (which managed research measures of the 3rd French National Alzheimer Plan 2008-2012). In Janurary 2015, I joined the INSERM (French National Institue for Health) as a tenured Researcher (chargé de recherche Inserm), and I am currently working in the Bordeaux Population Health research center INSERM U1219 (Bordeaux).

Scientific summary

       My research has mainly focused on the epidemiology of aging, with the aim of understanding how environmental factors, in particular diet, influences the etiology of brain diseases and conditions in aging such as dementia and cognitive decline. I have been working on several large cohorts, including the French Three-City study and Harvard cohorts (Nurses' Health Study and Women's Health Study), and I have developed a multidisciplinary epidemiological expertise across nutrition, neurosciences, applied biostatistics and brain imaging. Over the past years, I have evidenced protective associations of: fish and marine omega-3 fatty acids, olive oil, healthy diets (eg., a Mediterranean diet) and related nutrients, optimal cardiovascular health level; with healthy brain and general aging.

There is increasing evidence that many age-related diseases are determined by exposures over the entire life-course. For example, cumulative environmental exposures throughout life may modulate the burden of lesions and resilience capacities of the aging brain, which are the two core neuro-pathophysiological components of Alzheimer’s dementia. Hence, it has become more and more evident that brain aging research should move on early prevention. In this context, my current research objectives are two-fold. First, I aim at identifying in prospective cohort studies the time window and the mechanisms linking environmental risk factors to brain health, by using (i) dynamic methodological approaches to investigate risk factor trajectories, and (ii) innovative markers of: exposures (eg, metabolomics), outcomes (eg, brain imaging measures) and neurobiological mechanisms (eg, neurogenesis).  My second aim relates to the identification of relevant targets (population, agent) for early prevention. This includes exploration of gene-by-nutrient interactions in cognitive decline and dementia and investigation of potential novel preventive agents/combination through both candidate and agnostic approaches applied to omics data – with a specific interest on the food exposome.

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