Tenured Research Scientist, INSERM
Since 2014 Tenured Research Scientist, Grenoble Institute of Neuroscience, INSERM U836, Grenoble, France (Pr. F. Saudou)
2012-2014 Senior Postodc, Institut Curie, INSERM U1005, Orsay, France (Dr. F. Saudou)
2008-2012 Postdoc, Columbia University, Department of Psychiatry, New York, USA (Dr. C. Kellendonk)
2004-2008 PhD Student, University Paris VI, Center for Psychiatry and Neuroscience, INSERM U894, Paris, France (Dr. P. Sokoloff and J. Premont)
2003-2004 Pregraduate Student, University Montpellier II, Institute of Human Genetics, CNRS UPR1142, Montpellier, France (Pr. S. Lehmann)
2008 PhD in Neuroscience (University Paris VI)
2004 Master in Biochemistry and Neuroscience (University Montpellier II)
2012 ANR R-PDOC (BATMAN Project)
Dynamic remodelling of axonal connections is a sine qua none condition to adapt proper response to environmental stimuli. BDNF, the most abundant neurotrophin in the adult brain, is a key regulator of synaptic plasticity, axonal remodelling and dendritic sprouting. These functions are critical for high-order cognitive functions, long-term memory and behavioural adaptations to environmental changes. However, several crucial questions remain unanswered :
How does neuronal activity dictate the transport and release of BDNF in an activated axonal network ?
What are the molecular mechanisms that translate neuronal activity into a “go/no go” signal for BDNF axonal transport ?
What are the physiological consequences on the remodelling of fronto-striatal circuitry and on complex behavioral responses such as cognition, flexibility or working memory ?
Our research project aims to better understand the regulatory mechanisms that control the dynamic transport of BDNF in axons and more particularly in the fronto-striatal network.
Beyond its implication in fundamental science, our project may provide important insights for the development of new therapeutic strategies in neurological and psychiatric disorders that affect the corticostriatal network, such as schizophrenia, obsessive-compulsive disorder and Huntington's disease.
Techniques: To explore these fundamental questions, we use a combination of cell biology tools, time-lapse videomicroscopy, super-resolution microscopy, microfluidic systems, multielectrode arrays, electrophysiology, optogenetics, transgenic mice and behavior.