Michaël DEMARQUE PhD
Course and current status
Researcher (CR1) at INSERM
Postdoctoral associate in Dr C.Wyart team, ICM, Paris, France.
Postdoctoral associate in Dr N.C. Spitzer laboratory, UCSD, La Jolla, USA.
Using a multidisciplinary approach, immunocytochemistry, molecular biology, calcium imaging, extracellular recordings and focal electroporation, I studied the functional consequences of the activity-dependent specification of serotonin in the brain of the African clawed toad Xenopus Laevis
2004 PhD in Neurosciences - Aix-Marseille University, France
2000 Diploma of graduated studies (DEA) in Neurosciences Aix-Marseille University
1999 Master degree (maitrise) in biology-physiology Aix-Marseille university
1998 BS/BA (license) in biology-physiology Aix-Marseille university
1997 Diploma of Higher Education (DEUG) in biology-physiology Aix-Marseille University
My resesarch interests are focused on activity-dependent developmental mechanisms. I have been using a combination of physiological approaches (patch-clamp, extracellular recordings, calcium imaging), basic morphology and molecular biology techniques to study the contribution of electrical activity on different aspects of nervous system maturation. I am currently working on the develoment of the dopaminergic neurons in the zebrafish brain.
How do neurons acquire their identity, how do they integrate functionally into a network and how do neuronal activity and genetic programs interact to fine tune these developmental steps are few of the questions I'm interested in. The answers would contribute to a better understanding of neuronal network assembly and would open new perspectives for activity-based therapies. I believe increased knowledge on how new networks develop would also help understand how mature networks function.