Thierry Couffinhal is a graduate of the University of Bordeaux School of Medicine. He completed his clinical training in cardiology at the Haut Lévêque cardiological hospital. He completed a doctoral fellowship in vascular biology at the University of Bordeaux (Poste d’accueil Inserm, 1994), and a postdoctoral fellowship in Dr J.M. Isner’s lab (St Elizabeth Medical Center of Boston, Boston, USA, 1995-96.).
He joined faculty at the University of Bordeaux School of Medicine as an Assistant Professor of cardiology and rose through the ranks to become a Professor of Cardiology, head of the clinical unit of « Exploration, Prevention and Care Center for Atherosclerosis (CEPTA) ». This Unit is dedicated to exploration, prevention and long-term treatment and management of atherosclerotic diseases (angina and myocardial infarction, stroke, peripheral arterial disease) and primary prevention in high-risk patients. Explorations are based on non-invasive up-to-date echographic and other vascular tools. Management is based on a multidisciplinary approach integrating large therapeutic education programs. Thierry Couffinhal currently participates in 7 industrial or academic clinical research programs.
He has been at the head of an Inserm Unit (French Institute of Health and Medical Research) since 2007. The laboratory explores the role of major signaling pathways (Wnt / Hedgehog / JAK2) in vascular biology and thrombosis during development and diseases. The lab is specialized in vascular exploration of transgenic mouse models and signaling pathways. In the last ten years, his research group has been a pioneer, providing molecular and biochemical evidences for the dynamic role of the Wnt/Frizzled pathway in the vascular, cardiac and central nervous system. The group is currently looking at the molecular mechanisms of planar polarity in the oriented morphogenesis of the vascular network during development or diseases.
Experience in collaborative research:
Major contributions of Thierry Couffinhal in physiology, biology and vascular medicine :