Patrick Brest
  • E-mail :[email]
  • Phone : + 33 4 92 03 12 45
  • Location : Nice, France
Last update 2016-04-25 16:13:15.715

Patrick Brest Full Time INSERM Senior Resercher

Course and current status

2014: Habilitation à Diriger les Recherches (HDR)

2012: INSERM Researcher at  IRCAN Institute of Research on Cancer and Aging in Nice (IRCAN), CNRS UMR7284, INSERM U1081, University of Nice Sophia-Antipolis, Faculty of Medicine, 28 av de Valombrose 06107 Nice, FR (actual position)

2010-2011: INSERM Researcher at University of Nice Sophia-Antipolis EA4319/INSERM ERI21, Faculty of Medicine, Nice, FR

2007-2010: Postdoctoral fellow at INSERM ERI-21/EA-4319, Nice, FR

2004_2007: Postdoctoral fellow at Lund University, Lund, SE

2000-2004: Ph.D student at Université de Nice Sophia-Antipolis, Nice, FR

2000: Master of Science at Université de Nice Sophia-Antipolis, Nice, FR



Articles: 33

Sum of the Times Cited: 726

Sum of Times Cited without self-citations: 699

Citing Articles: 624

Citing Articles without self-citations: 608

Average Citations per Item: 22.00





SYNOTELO Project (Agence Nationale de Recherche) (Cancéropole PACA)

Tumor microenvironment Project (Fondation ARC pour la recherche sur le cancer)

Scientific summary

During my first 10 years of research activity, I have focused my work on how the environment modified cell responses. During my thesis, I  studied bacterial infection (or toxin exposure) and cell responses with a specific emphasis on gut mucosa (14 papers). During my postdocs, I  studied how epigenetic-related drugs (Histone deacetylase inhibitors) improved cancer drug therapies when used in combination in the particular HAMLET (Human Alpha_lactalbumin Made LEthal for tumor cells) molecules. More recently, I  focused my interest on the role of miRNA in this enhancer effect (5 papers, 2 patents).

Genetic variation and RNA stability

Nowadays, my research is more focused on the consequences of genetic variations on RNA stability. Lately, we proposed a model on how the environment (via miRNA expression) and genotype may interact with different issues in term of pathology. Thus, my research is now specially focused on this kind of interaction in human physiopathology (papers, 1 patent).

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