Date and place of birth: 04/08/1957 Paris France
Laboratory: INSERM U1151, Université Paris Descartes, Bâtiment Leriche, Porte 14, 14 rue Maria Helena Vieira da Silva 75014 Paris, France
University degrees :
Position : Chargé de Recherche INSERM 1986
EMBO fellowship Department of Pharmacology, University College London, Prs. DH JENKINSON and D COLQUHOUN, supervisor Dr.DC OGDEN, 1983-1986.
INSERM U442, Université Paris XI, 1986-2003
Research Assistant, Department of Neurophysiology, National Institute for Medical Research, Mill Hill, London, 1995-1998
INSERM U1003, Université Lille 1, 2003-2011
Assistant Professor, Université Lille 1, INTERFACE INSERM-Université 2003-2011
Research Evaluation: Scientific Board (Conseil Scientifique) Inserm 2012-2016
Editorial Board member:
World Journal of Gastrointestinal Pharmacology and Therapeutics
Research Keywords : human liver, calcium channels, cancer, circulating tumor cells
Competence: calcium imaging, electrophysiology, cell proliferation, cancer
My main project is aimed at the relation between calcium channels expression and cell proliferation. For several years, I have focused my work on the development of liver cancer. I have characterized the molecular nature of the channel involved and established the specific role of TRPC6, related to the transient receptor potential canonical (TRPC) family. TRPC6 is observed in human liver tumours and absent in livers from healthy patients I'm now investigating how TRPC6 expression is able to trigger abnormal cell proliferation and how growth factors control TRPC6 expression and the type of plasma membrane protein complexes built up to allow this specific calcium entry to trigger cyclins expression and activation in primary cultures of human hepatocytes. I am now opening up my field of expertise to other tissues such as prostate and breast.