Andrée Karyn julliard Associate Professor, PhD , Neuroscience

Course and current status

  • Lecturer in Zoology, Univ. Claude Bernard, Villeurbanne, France, September 1985 to August 1986 Ph.D. student,
  • Assistant Professor, Department of Cell Biology, Univ. Villeurbanne, France 1987- 1988
  • Research Associate, Electron Microscopy Center, Univ. Claude Bernard, Villeurbanne, France September 1998 to August 1990            
  • Research Engineer, Forensic Science Laboratory, Lyon France September 1990 to September 1991
  • Assistant Professor, Department of Neuroscience, Univ. Claude Bernard, Villeurbanne 1991- 1995
  • Associate Professor, Lab. Sensory Neuroscience, Behaviour, Cognition; Olfaction & Alimentation Team.- CNRS/Univ. Lyon 1, France1995- 2012
  • Head of the “Centre des Microstructures” Electron Microscopy Center (CTµ, electron and confocal microscopy platform) 2008-2011 http://microscopies.univ-lyon1.fr/
  • Associate Professor, Neuroscience Research Center (CRNL) Inserm U1028-CNRS 5292-UCB Lyon1 Team - Olfaction: From Coding to Memory, Lyon, France 2012-
  • Head of thematic “Olfaction and alimentation”
  • Director of « comités de sélection (CoSel) » for Associate Professor recruitment Section 69 (Neurosciences) 
  • Director of Master Program in Neurosciences University Lyon 1, France, 2008 http://spiralconnect.univ-lyon1.fr/webapp/website/website.html?id=5451026&read=true

Scientific summary

Olfaction and eating behaviors are intimately intermingled. Olfaction takes part in each step of the food intake from food choice, to its consumption. At the reverse, satiation reduces olfactory perception which contributes in meal interruption. Thus, olfactory cued reward responses to food stimuli are one of the important factors controlling food intake. In the face of obesity epidemic and the prevalence of various kinds of eating disorders, it is essential to better understand how olfaction is modulated by the nutritional status in a normal context and in which extend it is disrupted in pathological eating behaviors.

Our group has been one of the first to demonstrate in animal that the olfactory signal is under metabolic influences. Indeed we have shown that fasted animals have greater olfactory sensitivity than satiated ones. The action of molecules modulating food-intake is mainly established at the level of hypothalamic sub-nuclei. Here we tested the hypothesis that they also exert a powerful action on olfactory structures. Our behavioral experiments in rat showed that odor perception thresholds are modulated by intracerebro-ventricular infusion of ghrelin (orexinergic peptide) and insulin (anorexinergic peptide) which increased and decreased olfactory threshold, respectively. Moreover, we have investigated the influence of the metabolic state and intracerebro-ventricular infusion of insulin on the modulation of sniffing strategies known to be important in odorant intensity and identity perception. Insulin was shown to abolish the increase in sniffing frequency observed in fasted animal in response to food odor. Taken together, our results demonstrate that the olfactory system is intimately linked with the endocrine systems in order to optimize the olfactory processing to the nutritional needs of the organism.

Currently we investigate in normal and pathological contexts (metabolic disorders) (i) the influences of nutritional states on olfactory processing and (ii) the impact of metabolic cues on the olfactory system. To address these questions, we use a multidisciplinary set of convergent and interactive approaches to better understand the cellular basis of the olfactory sensitivity to metabolic cues and to characterize the olfactory processing in various pathological context (metabolic disorders).

 http://scholar.google.fr/citations?user=X_tWRUIAAAAJ&hl=fr

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