1985: Master (ex DEA) in Virology (Université Paris 7 & Institut Pasteur) - Supervisor: Pr. D. Paulin
1985-1986: National service
1986-1990: PhD in virology - Supervisors: Pr. Michel Morange and Dr. Olivier Bensaude (Institut Pasteur) - Title: "Two studies of the stressed cell in mammals": "Increased phsphate turnover on the heat-shock protein" and "Activation of cdc2-type and RNA-Polymerase-II CTD protein kinases"
1990-1992: Postdoctoral Researcher CNRS - Université de Rennes1 URA256 - Team: "Post-Transcriptional regulations and Development" (PI: Dr. H. Beverley Osborne)
1992-2015: INSERM Researcher - CNRS - Université de Rennes 1 - IGDR (UMR6290)- Team: "Genetic Expression and Development" (PIs: Dr. H. Beverley Osborne and Pr. Luc Paillard)
2016-: INSERM Researcher - INSERM - Université de Rennes 1 - IRSET (UMR1085) - Team: "Dynamics of Microenvironment and Cancer: Structure, Signaling, Contaminants” (Dymec) (PI: Nathalie Théret)
2004-2007: Elected member of Rennes-1 University's scientific board
2004-2008: Elected member of the CNRS scientific section 26 (Development, Evolution, Reproduction, Aging)
2008-2012: Elected member of Rennes-1 University's board
Scientific interests: Gene expression control, Development and homeostasis, Cellular micro-environment.
During the last years, I focused my research on the role of post-transcriptional regulations in development. I have characterized the role of the RNA-binding protein CELF1 (previously known as EDEN-BP) in regulationg the polyadenylation state, translation and stability of maternal mRNAs in amphibian embryos. More recently, thanks to CELF1_KO mice produced by Luc Paillard, Carole Gautier-Courteille, Chantal Kress and Charles Babinet, I have deciphered the role of CELF1 in lens homeostasis. I have identified by RNA-seq the CELF1 mRNA targets in lens, and more specifically those regulated at the level of pre-mRNA splicing. This project has given rise to a collaboration with the Salil Lacke's group (University of Delawware)
Beside this, I was involved in a collaborative project with Raphael Métivier on the spatial remodeling of the genome upon estrogen response.
Since january 2016, I joined the team leaded by Nathalie Theret, whose aim is to decipher the role of adamalysins in TGF-β activity during chronic liver diseases (Fibrosis and HCC). For this project, we implement complementary approchaes such as cell biology, biochemistry, functional genomics, system biology and modeling.