Vincent Legagneux
  • E-mail :[email]
  • Phone : 0223234685
  • Location : Rennes, France
Last update 2016-09-20 16:34:45.996

Vincent Legagneux PhD Biological Sciences

Course and current status

Education

1985: Master (ex DEA) in Virology (Université Paris 7 & Institut Pasteur) - Supervisor: Pr. D. Paulin

1985-1986: National service

1986-1990: PhD in virology - Supervisors: Pr. Michel Morange and Dr. Olivier Bensaude (Institut Pasteur) - Title: "Two studies of the stressed cell in mammals": "Increased phsphate turnover on the heat-shock protein" and "Activation of cdc2-type and RNA-Polymerase-II CTD protein kinases"

 

Post-doctoral Experience

1990-1992: Postdoctoral Researcher CNRS - Université de Rennes1 URA256 - Team: "Post-Transcriptional regulations and Development" (PI: Dr. H. Beverley Osborne)

1992-2015: INSERM Researcher - CNRS - Université de Rennes 1 - IGDR (UMR6290)- Team: "Genetic Expression and Development" (PIs:  Dr. H. Beverley Osborne and Pr. Luc Paillard)

2016-: INSERM Researcher - INSERM - Université de Rennes 1 - IRSET (UMR1085) - Team: "Dynamics of Microenvironment and Cancer: Structure, Signaling, Contaminants” (Dymec) (PI: Nathalie Théret)

 

Research Administaration

2004-2007: Elected member of Rennes-1 University's scientific board

2004-2008: Elected member of the CNRS scientific section 26 (Development, Evolution, Reproduction, Aging)

2008-2012: Elected member of Rennes-1 University's board

Scientific summary

Scientific interests: Gene expression control, Development and homeostasis, Cellular micro-environment.

During the last years, I focused my research on the role of post-transcriptional regulations in development. I have characterized the role of the RNA-binding protein CELF1 (previously known as EDEN-BP) in regulationg the polyadenylation state, translation and stability of maternal mRNAs in amphibian embryos. More recently, thanks to CELF1_KO mice produced by Luc Paillard, Carole Gautier-Courteille, Chantal Kress and Charles Babinet, I have deciphered the role of CELF1 in lens homeostasis. I have identified by RNA-seq the CELF1 mRNA targets in lens, and more specifically those regulated at the level of pre-mRNA splicing. This project has given rise to a collaboration with the Salil Lacke's group (University of Delawware)

Beside this, I was involved in a collaborative project with Raphael Métivier on the spatial remodeling of the genome upon estrogen response.

Since january 2016, I joined the team leaded by Nathalie Theret, whose aim is to decipher the role of adamalysins in TGF-β activity during chronic liver diseases (Fibrosis and HCC). For this project, we implement complementary approchaes such as cell biology, biochemistry, functional genomics, system biology and modeling.

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