Agathe Subtil PhD Cell biology

Course and current status

Current Position:

Director of research (CNRS).

Head of the laboratory Cell biology of microbial infection, Institut Pasteur

Education:                                     

2004

1996

1993-96

1989-93

Habilitation à diriger des recherches from the University Paris 5

PhD in Cell Biology from the University Paris 6

Teaching Assistant, University Paris 6

Undergraduate studies: cell biology, immunology, development; University Paris 6, Student at the Ecole Normale Supérieure de Paris

 

Professional Experience:             

2014

 

2005-14

2000

 

1997-99

1993-96

 

Head of the Laboratory “Cell biology of microbial infection”, Institut Pasteur, Paris

Principal Investigator of the “Chlamydia” team, Unit Biology of cellular interactions, Institut Pasteur, Paris

Chargée de Recherche, Centre National de la Recherche Scientifique (CNRS). Assistant professor at Institut Pasteur.

Postdoctoral Research Scientist at Cornell Medical College, New York, USA. Research subject: regulation of glucose transport

PhD in Cell Biology at the Institut Pasteur, Paris 

Scientific summary

The goal of the work of the laboratory is to gain knowledge on the normal behavior of the eukaryotic cell, and on its disruptions during an infectious process. We focus on the mechanisms of entry and intracellular fate of intracellular bacteria, ChlamydiaChlamydiae species pathogenic to humans, mainly Chlamydia trachomatis and Chlamydia pneumoniae, cause a number of diseases, including trachoma, pelvic inflammatory disease and pneumonia. Primary infections are often minor or asymptomatic; the consequences appear long after infection. Throughout their cycle in the host cell, chlamydiae remain in a membrane-bound compartment called an inclusion. We investigate the interactions between the bacteria and the cells during infection. We focus mainly on the functional study of proteins secreted by the bacteria into the host cytoplasm by a process called type III secretion. 

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