From 1989 to 1992, he prepared a PhD in the department of Geriatrics, Mount Sinai Medical Center, New York, USA under the supervision of Professor Howard Fillit and André Delacourte (Inserm, France), on “the role of proteoglycans in amyloidosis in Alzheimer's disease". He graduated from the University of Lille in October 1992
From 1992 to 1994, he was a post-doctoral fellow (funded by France Alzheimer Association) in the Inserm laboratory headed by Marc Mazzuca in Lille.
In October 1994, he has been appointed Research Associate by the CNRS (the French National Centre for scientific research). Since then, he has worked on Alzheimer disease and related disorders. He was involved in the initial characterization of tau aggregates among neurodegenerative disorders. He has then developed experimental models to better understand the role of post-translational modifications in tau aggregation and tau secretion.
Luc Buée is a French scientist (CNRS Research Director), Director of the Jean-Pierre Aubert Research Centre and Head of the Inserm laboratory « Alzheimer & Tauopathies » at the University of Lille, France. His group is also part of the laboratory of Excellence (LabEx) DISTALZ and the Centre of Excellence in Neurodegenerative disorders (LiCEND).
His group is currently working on the pathophysiological consequences of neurofibrillary degeneration and their links to the amyloid pathology in Alzheimer disease. His group was/is also involved in different international consortia.