Thierry Galli Membrane Traffic in Healthy & Diseased Brain

Course and current status

Thierry Galli is a former student of the Ecole Normale Supérieure of Lyon. He received his BSc in Biochemistry at the University Pierre and Marie Curie, Paris, in 1988, and his PhD at the Collège de France and the University Pierre and Marie Curie, Paris, in 1992. He then moved to the USA to carry out postdoctoral research in Professor Pietro De Camilli's laboratory at Yale University School of Medicine. There he worked on the molecular mechanism of regulated and constitutive exocytosis. In 1995, he took his first research appointment at the French National Institute of Health and the Curie Institute in the laboratory of Professor Daniel Louvard, and in 2001 he was recruited as Research Director at the Fer-à-Moulin Institute, Paris. In 2005, he was appointed as a Group Leader at the Jacques Monod Institute, Paris. In 2015, he was appointed head of the Psychiatry and Neuroscience Center, now Institute of Psychiatry and Neuroscience of Paris.


Positions and Employment

  • 2019-: Institute of Psychiatry and Neuroscience of Paris Director
  • 2015-2018: Center of Psychiatry and Neuroscience Director
  • 2013-: INSERM Research Director 1st class
  • 2009-2017: INSERM ERL U950 Director
  • 2005-2017: Group Leader of the team ’Membrane Traffic in Neuronal & Epithelial Morphogenesis’, Jacques Monod Institute, Paris
  • 2001-2012: INSERM Research Director 2nd class
  • 2000-2004: Group Leader of the team ‘Membrane Traffic and Neuronal Plasticity’, INSERM U536, Institut Du Fer-à-Moulin, Paris
  • 1995-2000: INSERM Researcher in the laboratory of Pr. D. Louvard, CNRS UMR 144, Institut Curie, Paris.
  • 1992-1995: Postdoctoral Research Associate of the Howard Hughes Medical Institute in the laboratory of  Pr. P. De Camilli (Yale University, New Haven, CT, USA).
  • 1988-1992: PhD student in the laboratory of Pr. J. Glowinski (INSERM U114, Collège de France, Paris).


Honors and Awards

  • 2016: Coup d'Elan of Fondation Bettencourt-Schueller
  • 2015: Rachel, Ajzen et Léon IAGOLNITZER Prize of Fondation Pour la Recherche Médicale
  • 2012 : Grand Prix à orientation fondamentale de l'Association Robert Debré pour la Recherche Médicale
  • 2007 : Editor with Peter Mc Pherson of the issue of Current Opinion in Cell Biology on ‘Membranes’
  • 2006 : Médaille de la Ville de Paris (Echelon Argent), Lauréat de la Subvention de la Ville de Paris en Recherche médicale et Santé (4 lauréats)
  • 2004: Contrat d’Interface INSERM-Université Paris VII (2004, renewed 2008)
  • 1999 : Action Concertée Incitative – Jeune Chercheurs du Ministère de la Recherche et des Technologies.
  • 1993 : Bourse de Recherche de la Philippe Foundation.
  • 1990 : Bourse Curien de Formation par la Recherche du Ministère de la Recherche et des Technologies.


Honorary activities

  • 2013-:        Director of ITMO BCDE
  • 2012-2013: Member of the Scientific Council of INSERM 
  • 2012-: Member of the EB of J Biol Chem
  • 2012-2013: President of the French Society of Cell Biology
  • 2010-2011: Vice-President of the French Society of Cell Biology
  • 2009-2016:  Editor in Chief of Biology of the Cell
  • 2008-2012:  Member of the INSERM Scientific Committee of Neurosciences
  • 2003-2008:  Associate Editor of Biology of the Cell
  • 2003-:         Editorial Advisor of the Biochemical Journal
  • 2002-2009:  Treasurer of the French Society of Cell Biology
  • 2002-2003:  Editor-in-chief of the Lettre des Neurosciences (French Neuroscience Society)
  • 2002-2012:  Member of the INSERM commission on workshops
  • 2001-2013:  Member of the Council of the French Society of Cell Biology
  • 2001-2010:  Member of the Editorial Board of Médecine/Sciences
  • 2001-2004:  Member of the INSERM commission on Prion Diseases
  • 1998-2002:  Founding member, Treasurer of the Club Exocytose
  • 1998-2001:  Member of the Neuroscience Committee of the University Pierre et Marie Curie

Scientific summary

T Galli's research focuses on the role of SNARE proteins in exocytosis mediating epithelial and neuronal cell differentiation, with particular emphasis on the tetanus neurotoxin-sensitive routes, mediated by cellubrevin/VAMP3 and synaptobrevin/VAMP2, the tetanus neurotoxin-insensitive routes mediated by TI-VAMP/VAMP7, and ER-Plasma Membrane contact sites regulated by Sec22b. We aim at understanding the role of secretory mechanisms in neuronal development and aging and in neurodegenerative diseases and brain tumours.

Selection of recent publications:

Wang GNola SBovio SCoppey-Moisann MLafont FGalli TBiomechanical control of lysosomal secretion via the VAMP7 hub: a tug-of-1 war mechanism between VARP and LRRK1. 

Petkovic M, Jemaiel A, Daste F, Specht CG, Izeddin I, Vorkel D, Verbavatz JM, Darzacq X, Triller A, Pfenninger KH, Tareste D, Jackson CL, Galli T. The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion. Nat Cell Biol. 2014 Apr 6. doi: 10.1038/ncb2937.

Larghi P, Williamson DJ, Carpier JM, Dogniaux S, Chemin K, Bohineust A, Danglot L, Gaus K, Galli T§, Hivroz C§. (2013) VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites. Nat Immunol. doi: 10.1038/ni.2609. § co-senior authors.

Burgo A., Proux-Gillardeaux, V., Sotirakis, E., Bun, P., Casano,A., Verraes, A., Liem, R., Formstecher, E.,  Coppey, M. Galli, T. (2012). A molecular network for the transport of the TI-VAMP/VAMP7 vesicles from cell center to periphery. Developmental Cell, 23:166–180.

 Zylbersztejn K, Petkovic M, Burgo A, Deck M, Garel S, Marcos S, Bloch-Gallego E, Nothias F, Serini G, Bagnard D, Binz T, Galli T. (2012). The vesicular SNARE Synaptobrevin is required for Semaphorin 3A axonal repulsion.  J Cell Biol 196:37-46. (F1000=8) 

Danglot L*, Zylbersztejn K*, Petkovic M*, Meziane H, Combe R, Champy Mf, Birling Mc, Pavlovic G, Bizot Jc, Trovero F, Della Ragione F, Proux-Gillardeaux V, Sorg T, D’esposito M, Galli T. (2012). Absence of TI-VAMP/Vamp7 leads to increased anxiety in mice. J Neurosci 32:1962-1968 (F1000=6) 

Danglot L, Chaineau M, Dahan M, Gendron M-C, Boggetto N, Perez F, and Galli T. (2010).  Role of TI-VAMP and CD82 in EGF receptor cell surface dynamics and signaling. J Cell Sci 123:723-35.

Burgo A*, Sotirakis E*, Simmler MC, Verraes A, Chamot C, Simpson JC, Lanzetti L, Proux-Gillardeaux V§, Galli T§. (2009). Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth. EMBO reports 10:1117-24.

Scheuber, A.*, R. Rudge*, L. Danglot*, G. Raposo, T. Binz, J.-C. Poncer, and T. Galli. (2006). Loss of AP3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses. Proc. Natl. Acad. Sci. USA 103:16562-7.

Proux-Gillardeaux V., Gavard J., Irinopoulou I., Mège R.-M., and T. Galli. (2005) Tetanus neurotoxin-mediated cleavage of cellubrevin impairs epithelial cell migration and integrin-dependent cell adhesion. Proc. Natl. Acad. Sci. USA 102:6362-6367.

Image d’exemple