Alexandra Gros
  • E-mail :[email]
  • Phone : +441312429474
  • Location : Edinburgh, Royaume-Uni
Last update 2017-11-03 12:11:58.725

Alexandra Gros PhD Neuroscience

Course and current status

2016 - Present: Post-doctoral researcher - The university of Edinburgh (CCBS), UK                       Writer for the Neuroscience CNRS blog "Aux frontières du cerveau" (https://lejournal.cnrs.fr/nos-blogs/aux-frontieres-du-cerveau)

2015 - 2016: Post-doctoral researcher - Neuroscience Paris-Saclay Institute (NeuroPSI) / CNRS, France

2015: PhD student in Neuroscience - University Paris-Sud / Neuroscience Paris-Saclay Institute (NeuroPSI), France -  "Neurogenèse adulte hippocampique : Rôle fonctionnel dans la mémoire épisodique et recrutement des nouveaux neurones lors de la mémorisation" - Thesis directors: Dr. Serge Laroche and Dr. Alexandra Veyrac

Scientific summary

Field of expertise

  • Hippocampal Adult Neurogenesis
  • Neuronal plasticity
  • Behavior including spatial, episodic and everyday spatial memory
  • Immunochemistry
  • In situ hybridization (catFISH)
  • Immediate early gene, Zif268
  • Animal Well-being

 

Research

During my PhD, I studied the role of adult hippocampal neurogenesis in long term episodic memory using a new episodic memory task based on the presentation of occasional episodes allowing rats to encode “What – Where – In which context” information. Using irradiation, we showed that adult hippocampal neurogenesis contributes significantly to the consolidation and faithful recall of episodic memory. Furthermore, we showed that the immediate-early gene, Zif268, plays a crucial role in the selection and recruitment of newborn hippocampal neurons by learning during their critical period of integration in hippocampal neural networks.

Now, using a behavioral taging and capture task (appetitive spatial delayed-matching-to place task), similar to daily experience in humans, I study the hippocampal neuronal network involve and these changes during normal aging. We hypothesise that the cell assembly representing the behaviour event that facilitates the memory and the cell assembly representing the memory encoding event should have significant overlapping in the brain areas involved in memory formation, such as hippocampus. This hypothesis is derived from the synaptic tagging and capture theory (Redondo and Morris, 2011). 

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