Jean-Sébastien Silvestre
  • E-mail :[email]
  • Phone : +33153988060
  • Location : Paris, France
Last update 2017-07-27 15:00:54.745

Jean-Sébastien Silvestre PhD - Cardiovascular Pathophysiology - Research Director INSERM

Course and current status


I obtained my PhD in cardiovascular physiology from the University of Paris 7 in 1998. I was then a research fellow in Prof. Henry M. Sucov’s laboratory at the Institute of Genetic Medicine, University of South California, (Los Angeles, USA) from 1998 till 1999. In 1999, I started my independent research career as an associate professor (Paris-Diderot university) at the Cardiovascular Research Center Inserm Lariboisière (Lariboisière Hospital, INSERM U689) where my team made significant achievements deciphering the molecular pathways involved in post-ischemic vessel growth by combining genetic approaches in the mouse with a wide range of cell and molecular biology methods. In 2008, I successfully passed the competitive entrance examinations to the National Institute for Health and Medical Research (INSERM) where I was instantly appointed Research Director. In 2009, I moved to the Paris Cardiovascular Research Center – INSERM UMRS 970 (Georges Pompidou European Hospital) where I am leading a team working on regenerative therapies for cardiac and vascular diseases.


  • 2015 Research director, 1st class, INSERM, Paris, France
  • 2008 Research director, 2nd class, INSERM, Paris, France
  • 2006-2008 Honorary member, Institut Universitaire de France
  • 2003 Accreditation to supervise research, University Paris 7, Paris, France
  • 1999-2008 Associate professor, University Paris 7, Paris, France
  • 1998-1999 Post-doctoral position. Institute of Genetic Medicine, University of South California, Los Angeles, USA
  • 1995-1998 PhD Student, INSERM U127, University of Paris 7, Paris, France



  • 2014-present Director team 6, « Regenerative therapies in cardiac and vascular diseases », PARCC/Inserm UMRS 970, Paris, France
  • 2008-2013 Director, team 6, « Therapeutic angiogenesis », PARCC/Inserm UMRS 970, Paris, France
  • 2004-2008 Co-director, team 2 « post-ischemic angiogenesis», CRCIL Inserm U689, Paris, France
  • 2005-present   Phd Student: 9 since 2005



  • 2016-present Scientific referent ERA-NET cardiovascular diseases, European Union
  • 2016-present Program Manager for the French National Research Agency
  • 2016-present, Associate Editor, Frontiers in Cardiovascular Medicine
  • 2013-2015 Co-organizer of the 5th & 6th meeting of the French Society of angiogenesis
  • 2012-2015 Member of board directors of CORDDIM-Region île de France
  • 2010-present Editorial Board, Arterioscler Thromb Vasc Biol
  • 2013-present Expert for European Research Council (Advanced grant), Diabetes Wellness Network Sverige (Sweden), Science Foundation Ireland (Ireland), Swiss National Science Foundation (Switzerland), National Science Center (Poland), Institut Universitaire de France, French Research National Agency, French High Council for Evaluation of Research and Higher Education
  • 2008-2011 Member of board directors of French Society of Angiogenesis



  • 2016 Team labelled by Fondation pour la Recherche Médicale
  • 2014-2018 Award for scientific excellence INSERM
  • 2012 Team labelled by Fondation pour la Recherche Médicale
  • 2012 Excellence research chair program, Paris 5 University
  • 2010-2014 Award for scientific excellence INSERM
  • 2007-2012 Excellence research chair program INSERM & Assistance Public – Hôpitaux de Paris
  • 2006 Honorary member of Institut Universitaire de France
  • 2005 French National Research Agency, Young Investigator award
  • 1998 SEARLE young investigator award, Aldosterone conference, Jun 1998, New Orleans, USA

Scientific summary

Jean-Sébastien Silvestre, PhD: senior research director at the French National Health and Medical Research Institute (INSERM).  My work focus on the identification of molecular and cellular mechanisms regulating key events in post-ischemic tissue remodelling with potent revascularization and regenerative therapeutic promise. Since, 1995, I am a co-author of 85 original research papers and over 40 reviews or book chapters.

Researcher ID:

Keywords: Cardiovascular diseases, Ischemia, Regenerative medicine, Inflammation, Stem cells

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