• E-mail :[email]
  • Phone : +33 65 99 36 61 07
  • Location : Paris, France
Last update 2017-09-18 18:31:56.281

herve puy Full Professor in Biochemistry and Molecular Biology Medicine University Paris Diderot

Course and current status

2010- : Head of the “Pôle of Biology” Universitary Hospital Paris Nord Val de Seine

2014-2019:  Head of the research unit Inserm U1149 CRI, team 4

Scientific summary

Main research interest: Heme biosynthesis, iron metabolism and porphyrias: molecular epidemiology and pathophysiology : Co-head of INSERM Unit U1149 CRI: research center on inflammation; Pôle de Recherche et d'Enseignement Supérieur, Sorbonne Paris-Cité, Paris, France. “Heme iron and inflammatory  diseases”
My topic is focused on the heme and iron metabolism and erythropoiesis including pathologies related thereto (porphyria, hemochromatosis, microcytic anemia). My projects are driven largely by the clinical activity of the French Porphyrias Centre (Hôpital Louis Mourier), the molecular diagnostic activity of rare microcytic anemia, conducted genetic Hospital Bichat Laboratory of Biochemistry. All these translational and clinical activities take place inside the Pôle of biology that I manage.
The metabolism of iron and heme are closely linked, because of the need to coordinate the synthesis of protoporphyrin IX and iron bioavailability to ensure good control of the synthesis of heme erythroid precursors in the bone marrow in the liver and in the kidney. Recently we are mainly involved in:
• The iron, heme and erythropoiesis during erythropoietic porphyria, anemia of inflammatory conditions, genetic microcytic anemias associated with abnormal metabolism of iron and Aplasia.
• The role of hepcidin in iron homeostasis in the liver, kidney, intestine and control of bacterial infections.
• The pathophysiology and treatment of hepatic porphyria attacks and the response to treatment with exogenous heme related to oxidative stress and inflammation.

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