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  • Location : Paris, France
Last update 2017-09-06 10:28:34.511

Renato MONTEIRO Professor in Immunology, MD, PhD

Course and current status

Renato  Monteiro  is  professor  of  Immunology  at  Paris  Diderot  University  and  head  of  the   Center  for  Research  on  Inflammation  –  INSERM  U1149  &  CNRS  ERL8252  located  at  Bichat   Hospital  campus  in  Paris.  After  obtaining  his  medical  degree  in  Brazil  and  then  completing   a  residency  in  nephrology,  he  moved  to  Paris  in  1982  to  study  nephrology  at  the  Necker   Hospital  under  the  mentoring  of  Professor  Jean  Berger.  Prof.  Monteiro  was  awarded  the   1986  Prize  of  the  French  Society  of  Nephrology  for  his  work  on  IgA  nephropathy,  notably   for  the  identification  of  abnormal  IgA  in  Berger’s  disease.  He  later  studied  immunology  at   the  University  of  Birmingham  in  Alabama  with  Professor  Max  Cooper.  Prof.  Monteiro’s   work  in  Prof.  Cooper’s  lab  led  to  the  identification  of  the  IgA  Fc  receptor  I  (CD89).  He   defended  his  PhD  thesis  in  immunology  in  1993  at  Paris  Diderot  University.

Scientific summary

 
Professor  Monteiro  made  important  discoveries  in  the  field  of  IgA  and  Fcα  receptors.   His  research  group  identified  CD71  transferrin  receptor  as  an  IgA1  receptor  and  pioneered   work  in  involvement  of  CD89  and  CD71  in  diseases  involving  the  IgA  system  such  as  IgA   nephropathy,  Henoch-Schönlein  purpura,  spondylitis,  alcoholic  cirrhosis,  and  celiac  disease.   His  team  identified  an  unsuspected  function  for  CD89  and  SIGNR1,  and  beyond,  a  new  role   for  these  molecules  as  dampers  of  the  immune  system.  They  demonstrated  for  the  first   time  that  CD89  can  play  an  inhibitory  role  of  cell  activation  besides  its  known  role  in  cell   activation.  When  occupied  by  monomeric  IgA  or  when  targeted  by  anti-receptor  Fab   fragment,  CD89  can  promote  sustained  inhibition  of  cell  activation  opening  new   therapeutic  approaches.  Prof.  Monteiro  was  awarded  the  2010  Prize  of  the  French  Society   of  Immunology  for  his  work  on  CD89.

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