Signaling downstream of activated RTK receptors/ Fes and Fer kinases
Socs proteins and KIT signaling
Cloning and characterization of Socs1, a negative regulator of signaling
Genetics and developmental biology
Nobel price, François Jacob Laboratory
Member of the committee Ligue Contre le Cancer Ile-de-France 2014-now
Member of the committee -Plan Cancer “Formation à la recherche translationnelle” 2014-now
Member of the LIF panel, Marie Sklodowska-Curie Individual Fellowships
Member of the Master committee “Développement et Immunologie”, Aix-Marseille University
Characterization of kinases involved in cell transformation
Signalling proteins and especially kinases are considered as promising therapeutic targets in cancer. While a lot of attention is focused on few well characterized classical signalling pathways, we postulate that pathologic signalling is still largely unknown and as a consequence a number of essential targets are currently ignored.
Over the last few years, we have performed screens aiming at identify original novel essential effectors of signalling pathways downstream of the oncogenic c-Kit receptor.
Our current project is split into two axes: a continuation of our search for original signalling targets, and a study of two related kinases FES and FER, previously identified as essential signalling effectors in some leukaemia cells, and their implication in oncogenic mechanisms.