Stefano Marullo MD, PhD biochemistry

Course and current status

Stefano Marullo, MD, PhD  Short CV

Borne in Rome, Italy  (November 3rd,1955)               

Research Director (Except. Class) of the INSERM

1987:    Medicine Thesis, University of Paris Diderot.
1990:     PhD in Sciences (Biochemistry), University of Paris Diderot.

2002-Pres.:        Research Director (INSERM, Except. Class since 2013), Principal Investigator, team “receptor signaling and molecular scaffolds”, Institut Cochin, Paris
2012-Pres.:    Vice-President for Research, Paris Descartes University

1979-1986:    Resident of Paris Hospitals (Internal Medicine, Hematology)
1987-1995:    Associate Physician, Department of Immuno-Hematology St. Louis Hospital, Paris
1986-1990:    Research Fellow, then Senior Scientist (1988), Laboratory of "Molecular Biology of Receptors", Institut Pasteur, Paris
1990-1995:    Senior Scientist and Research Director (1992), Laboratory of Molecular Immuno-pharmacology, Institut Cochin de Génétique Moléculaire (ICGM), Paris
1995-1997:    Visiting Scientist, Biochemistry Department, Regis Kelly Laboratory, University of California San Francisco, USA
1998-2001:    Principal Investigator, CNRS Laboratory of Cellular and Molecular Pharmacology of Membrane Receptors, ICGM, Paris
2002-2008:    Co-chair Department of Cell Biology, Institut Cochin, Paris
2005-2012:    Associate Professor, University Paris Descartes
2008-2012:    Vice-Director of the PhD Program (B3MI), Universities Paris Diderot and Paris Descartes

1984     Fellowship, ”Ministère de la Recherche et de l'Enseignement Supérieur”
1987    Research fellowship, “Fondation pour la Recherche Médicale” (FRM)
1995    Research fellowship, NATO (visiting scientist)
1996    Research fellowship, FRM (visiting scientist)
1998    New-Team Starting Grants: FRM and the Association pour la Recherche sur le Cancer (ARC)
2012    “FRM-team” award

74 original articles in international journals, including: Blood, Cell, EMBO J, FASEB J, J Clin Invest, Mol Biol Cell, Mol Cell, Mol Cell Biol, Nat Biotechnol, Nat Comm, Nat Immunol, Nat Med, Nat Methods, Mol Psychiatry, PNAS, Science.
27 review articles, 10 book chapters, (>5800 citations, HI: 41)

Emorine et al, Science 245: 1118 (1989)
Marullo S et al, Nat. Biotechnol. 7: 923-927 (1989)
Magnusson Y et al, J Clin Invest, 86: 158 (1990)
Loisel TP et al, Nat Biotechnol, 15:1300 (1997)
Perretti M et al, Nat Med, 8: 1296 (2002)
Bourougaa K et al, Mol Cell, 38:78 (2010)
Coureuil M et al, Cell, 143:1149 (2010)
Bernard S et al. Nat Med, 20:725–731 (2014)
Lima-Fernandes E et al. Nat Commun, 5:4431 (2014)
Doly S et al., Mol. Psychiatry doi: 10.1038/mp.2015.1072 (2016) in press

1988: US 88. 03475; accepted US 5.242.822 (1993), UE 89 400 768.1.(1994) ; licensed 1989
1989: 89.00918; accept. UE 04.55.682 (1993), US 5.288.607 (1994), JPN 3050238 (2000); licensed, 1996, 2000.
1994: 94.04861
1997: 97.04476; extension UE JPN (100-999); accepted US 6.713.278; licensed 2002, 2009
2001: US 10/38.010, licensed, 2001.
2011: UE 10306215.4

Am J Physiol, BBRC, Biochemistry, Blood, Cell, EMBO, EMBO Rep, FEBS letters, J Biol Chem, J Cell Sci, Mol Pharmacol, Nat Methods, Neurochem, PlosPathogens, PNAS, Traffic, Trends Mol Med, Nat Methods, Trends Pharmacol Sci.
Université Libre de Bruxelles (Belgium), FRSQ, FCI, Génome Québec, McGill University (Canada), MRC, Wellcome Trust Fund, BSSRC (UK), NHMRC, Raine Foundation (Australia), Swiss National Science Foundation (Suisse), Human Frontieres (Intl.), Ministère de la Recherche, Ville de Paris, ANR, AERES/HCERES (France).

2008, 2009, 2015 ANR (blanc)

2009, ANRS
2010, Ligue contre le Cancer
2013, Equipe FRM
2014, INCA

PhD students: 7 (D Roulot; H Issafras; H Storez; L Achour; C Boularan; H Shirvani; G Gäta)
Post-Docs: 6 (B Bertin; R Jockers; M Mohr; MGH Scott; RA Alexander; S Doly)

Scientific summary

G protein coupled receptors (GPCRs), the largest family of membrane receptors, are implicated in a wide range of human diseases. Signal outputs resulting from their activation depend on their subcellular location and their local interacting partners, among which beta-arrestins (barrs) play a major role. Our project focuses on emerging paradigms of regulated GPGR and barr subcellular trafficking, from mechanistic molecular aspects to physiology and pathology.

The principal specific aims of our project are (Project Leaders):
-Deciphering cellular and molecular mechanisms involved in regulated GPCR export to the cell surface; pathophysiological implications (S Marullo)
-Investigating molecular basis of the interaction between pathogens and receptors for cell adhesion and signaling (S Marullo)
-Exploring mechanisms and functions of the nuclear trafficking of the regulatory scaffolding proteins barrs (H Enslen, M Scott)
-Deciphering new GPCR/barr-dependent mechanisms that regulate cell adhesion (H Enslen)
-Studying GPCR/barr-dependent mechanisms that regulate the anti-oncogenic PTEN phosphatase functions (M Scott)

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