CV Science

Patrick Chames PhD Immuno oncology, Research director

Course and current status

Group leader at Centre de Recherche en Cancérologie de Marseille (CRCM)

Research director (CNRS)
Antibody therapeutics and Immunotargeting (ATI)

Cancer Research Center of Marseille (CRCM)

Aix-Marseille Univ, CNRS, INSERM, IPC

Protein engineer with strong interest in antibody-based cancer immunotherapy Specialties:Molecular evolution, phage display, nanobodies, single domain antibodies

Scientific summary

Patrick Chames obtained his phD at the "University de la Méditerranée", Marseille, France in 1997 in the field of antibody engineering. From 1997 to 2001, he worked in the laboratory of phage display pioneer Hennie R. Hoogenboom where he isolated by phage display the first human antibody fragment specifically binding to a cancer related class I MHC complex (TCR-like antibodies). From 2001 to 2005, he worked for a french start-up company (Cellectis SA, Paris) in the field of genome engineering where he significantly contributed to the set up of an in vivo method, leading to the isolation of homing endonucleases capable of performing specific double strand break in a whole genome. In 2005 he accepted a permanent position for the French National center for research (CNRS). Since 2009, he is working for the French institute for health and medical research (INSERM, Marseille, France) in the field of therapeutic bispecific antibodies and blocking antibodies and is specialized in the use of single domain antibodies. Since 2012 he is a team leader in the Cancer Research Center of Marseille (CRCM).