Frederic Delom
  • E-mail :[email]
  • Phone : +33 5 56 33 04 29
  • Location : Bordeaux, France
Last update 2019-09-09 14:52:03.846

Frederic Delom Anterior gradient proteins, Tumor Niche & Secretome

Course and current status

From 2016: Head of the group “AGR, Tumor Niche & secretome”, INSERM U1218, Bordeaux, France

2013: Habilitation à Diriger la Recherche (HDR)

From 2011: Assistant Professor, University of Bordeaux, Bordeaux, France

2007 - 2010: Research fellow position, Barts and The London, London, UK

2004 - 2006: Post-doctoral position, McGill University, Montreal, Canada

2001 - 2004: Scientist position, Aventis Pharmaceutical Company, Paris, France

2001: PhD, INSERM U38, Marseille, France

Scientific summary

Our research group “AGR, Tumor Niche & Secretome” (ARTiSt) aims at understanding how tumor cells initiate and maintain a tumor niche which favors tumor development. Through the release of specific extracellular signals, cancer cells recruit/activate non-transformed host cells such as immune or endothelial cells. Then the material (proteins, lipids…) secreted by both cancer and stromal cells, shapes the extracellular proteome which in turn plays a critical role in controlling the establishment of a protumoral tumor niche. In particular, our work as brought us to focus on the Anterior GRadient (AGR) family of proteins which act on the tumor niche through 2 different modes including intracellular and extracellular functions. This occurs either intracellularly via the control of Endoplasmic Reticulum (ER) proteostasis, by affecting tumor or stromal cells secretomes, or extracellularly, when AGR proteins are secreted and act as pro-oncogenic factors. The objectives of our research group are to explore:

1 - How intracellular AGR (iAGR) proteins in tumor cells can impact on the tumor niche: We investigate how iAGR proteins, by regulating ER proteostasis capacity, could have an impact on the nature of the tumor cell secretome, and consequently contributing to the initiation and development of tumor niche.

2 - How extracellular AGR (eAGR) proteins signal towards tumor and stromal cells: We investigate how eAGR proteins, as microenvironmental factors, could have an impact on cancer and stromal cells in tumor-associated processes.

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