denis vivien
  • E-mail :[email]
  • Phone : 0231470166
  • Location : Caen, France
Last update 2011-03-25 08:46:18.539

denis vivien Professor in Neurosciences (PRE1), University of Caen Lower Normandy, Senior member of the Institut Universitaire de France (IUF 2009)

Course and current status

1993-94   Research fellow at the laboratory of Dr Joan Massagué, New York,

USA, Sloan Kettering Cancer Center, Howard Hughes Institute.

1995-2001   Associate Professor in Molecular Biology at the University of Caen.

1996  Habilitation

2001- Professor in Neurosciences, University of Caen.

2004- Vice-head of the UMR6185 CNRS/University of

 Caen“neurodégénèrescence et stratégies thérapeutiques”, GIP Cyceron

2005-2008 Head of the INSERM-avenir unit “tPA in the working brain”, GIP Cyceron, Caen.

2007- Chairman of the department of cellular, molecular and physiology of Cyceron.

2008- Head of the INSERM laboratory U919 “Serine proteases and

Pathophysiology of the neurovascular Unit”, team SP2U UMR CNRS 6232

CINAPS – GIP Cyceron


Other experiences and Professional Memberships

- Coordinator of the Master’s Research and Professional degree in « Neuroscience and Health

Imaging » (M1 and M2) in collaboration between the Departments of Medicine and Biology of the University of Caen.

- Coordinator of the European Network of Excellence “Diagnosis In Molecular Imaging”, DIMI, 6 PCRDT (03/2005-2010) for the GIP Cyceron (partner 42).

- Group leader and workpackage coordinator within the framework of the European Network Eurostroke (Arise + Eustroke) – 7 FP (2008-2013).

-  Scientific Advisor for the pharmaceutical group PAION (Aachen, Germany), for ProteA (Caen).

- Committee member for section 69 (neurosciences) of the University’s National Committee (CNU).

- Committee member for section 1 “Neuroscience, Neurology and Neuropsychiatry” INSERM, CSS1.


Scientific summary

Research interest: Since 2005, our work has mainly investigated the role of serine proteases in the control of the molecular and cellular events occurring during ischemic stroke and spinal cord injuries. Initially focused on the influence of serine proteases in the control of the N-Methyl-D-Aspartate glutamatergic signalling and neurotoxicity, our research has now extended to the role of serine proteases in the control of the homeostasis of the neurovascular unit. In addition, our approaches get closer and closer to the clinic, with as objectives, the development of original tools for diagnostic and therapeutic applications. For further details or extended CV please visit the Neurovascular Research Laboratory website at 


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