Benoît Ho-Tin-Noé PhD Pathophysiology and Cell Biology
Course and current status
2009-present Full-time researcher (CRCN) at INSERM Unit 698/1148, Laboratory for Vascular Translational Science, Bichat Hospital, Paris, France.
2006-2008 Postdoctoral fellow at The Wagner Lab, Immune Disease Institute, Department of Pathology, Harvard Medical School, Boston, MA, USA.
2002-2005 PhD Pathophysiology and Cell Biology at INSERM Unit 698 “Cardiovascular Remodeling”,
Université Paris VII Denis Diderot, Paris, FRANCE.
1999-2002 Master of Science (Summa cum Laude), Vascular Cell Biology and Physiology, Université Paris VII Denis Diderot, Paris, FRANCE.
1997-1999 Bachelor of Science (Cum Laude), Cell Biology, Université Paris VII Denis Diderot, Paris, FRANCE.
Scientific summary
During my PhD (October 2002- December 2005), I studied the mechanisms of pericellular proteolysis and its deleterious consequences on cell adhesion, organisation and survival. Our hypothesis was that plasmin-mediated extracellular proteolysis could play a role in the induction of smooth muscle cell apoptosis, a phenomenon that contributes to the evolution of aneurysms and to the destabilization of atherosclerotic plaques.
In February 2006, I joined The Wagner Lab (Immune Disease Institute, Department of Pathology, Harvard Medical School) that is specialized in intravital microscopy techniques applied to the study of thrombosis and inflammation in mice. My postdoctoral project consisted in investigating the role of platelets in the regulation of vascular integrity at sites of acute leukocyte recruitment and in tumors, in which the cellular and molecular mediators of inflammation are also thought to play a role.
I was recruited as a tenured researcher (CRCN) by INSERM in February 2009.
My research group is affiliated to the University of Paris and to the Team 6 of the Laboratory for Vascular Translation Science, Inserm U1148. Our research focuses on the mechanisms underlying thrombolysis resistance and on how platelet/leukocyte interactions contribute to the pathophysiology of vascular diseases and solid cancers.
