Hospîtal Practitioner – Anesthesiology and Intensive Care
TITLES AND CERTIFICATIONS
1999 Master 2, University of Paris VII
2001 MD, University of Nantes
2006 PhD, University of Nantes,
- 1994-2001 : Resident - Anesthesiology and Intensive Care Department. University Hospital Nantes
- Interface Contract -INSERM/CHU Nantes Since 2008
- Scientific Grants: SFAR (2001-2004) FRM (1999)
FIVE MAJOR PUBLICATIONS:
My work was articulated around sveral complementary projects concerning the beta3 adrenoceptor in the cardiovascular system
We identified the presence of β3-ARs on internal mammary artery endothelium, an artery used as graft for the myocardial revascularisation. Their stimulation induces a vasodilation dependent of nitric oxyde (NO). These receptors could prevent vasospasm after coronary artery bypass surgery.
Currently, the cellular targets of a third generation β-blocker efficient in systemic hypertension and heart failure, nebivolol, being poorly characterised, we shown that it activates β3-ARs both in rat thoracic aorta and in human myocardium.
The overexpression of β3-AR by using an adenoviral vector, leads to pro-angiogenic effects in various angiogenesis assays.
In endotoxemic shock, the β3-AR induced vasodilation is decreased, and is partly compensed by β1- and β2-AR activity potentialisation.
Taken together theses results highlight the potential role of β3-AR in various cardiovascular diseases.