• E-mail :[email]
  • Phone : +33 4 91 22 35 09
  • Location : Marseille, France
Last update 2011-08-09 12:41:32.75

Christophe GINESTIER PhD Oncology, Breast Stem Cells

Course and current status

Since 2009: Centre de Recherche en Cancérologie de Marseille,

                      U891, INSERM, Marseille, France

                     Research investigator, Molecular Oncology Lab

research project :

Characterization of normal and malignant mammary stem cells

Breast primary tumor xenobank establishment 

2006-2009: University of Michigan, Comprehensive Cancer Center, Ann Abor, MI, USA

                      Postdoctoral Research Fellow in Max Wicha’s Lab

Postdoc research project :

Characterization of normal and malignant human mammary stem cells

Identification of ALDH1 as a normal and malignant mammary stem cells marker

Role of BRCA1 in Regulation of Human Mammary Stem/Progenitor Cell Fate 

2002- 2005 :Molecular Oncology Lab, INSERM/U519, Marseille, France 

                      PhD supervisor : Dr Daniel Birnbaum

                     PhD fellowship from French Ministry of Research

 PhD research project :

Molecular taxonomy of breast cancers

Identification of Subclasses of Breast Cancer by Protein Expression Profiling

ERBB2 target: Gene Expression Signature and Herceptin resistance

Genome Alterations (amplifications, fragile sites) 

2001 - 2002 : Molecular Pathology Lab, IPC, Marseille, France

                       Master degree Supervisor: Dr Jocelyne Jacquemier

Project :

Distinct and Complementary Information Provided by Use of Tissue and DNA Microarrays in the Study of Breast Tumor Markers

Scientific summary

Role of breast cancer stem cell in mammary carcinogenesis

My scientific project is focused on understanding the various steps of breast carcinogenesis development. I study the hierarchical relationships between cells in normal and malignant breast epithelium in order to gain insight into the processes that underlie tumor initiation and development, and metastasis formation. The primary aim is to characterize and to understand the regulation of mammary epithelial stem cells since these are likely to be the targets of cancer-initiating events, and may be the underlying tumorigenic cells in breast cancers. The secondary aim is to characterize the breast cancer stem cell population of various tumor subtypes to identify new markers and therapeutic targets and use the cancer stem cell concept at the clinical level to manage the disease.


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