Full-time researcher (Directeur de Recherche DR2) of the Institut National de la Santé et de la Recherche (INSERM) at the unit U676.
Research fields: Cell death, apoptosis, cerebrovascular disease, neonatal ischemia, neuroprotection in experimental models.
PRODUCTION AND SCIENTIFIC DIRECTION
- 88 original papers, 12 review papers and book chapters, 15 invited lectures
- 12 Master students, 6 PhD students.
Stroke is a disorder affecting the life of all age groups, particularly those at the opposite ends of the age spectrum. It is now clear that induction of hypothermia in infants who had perinatal asphyxia results in improved neurological outcomes in survivors but to date no neuroprotective strategy is available in the setting of neonatal stroke. The overall hypothesis of this project is, that if we can both modulate the reperfusion phase after arterial occlusion to reduce early reperfusion injury as well as enhance repair by salvage kinases activation, we can restore function even after a major insult. To our knowledge, this project would be the first study at the international level to investigate modulation of reperfusion in a model of cerebral neonatal ischemia-reperfusion in the P7 rat pup.
The specific aims of this project can be declined as follow:
- Validation of ultrasound imaging to define hemodynamic changes through the circle of Willis during reperfusion and reperfusion modulation,
- Time-course of salvage kinases activated during reperfusion and their activation during reperfusion modulation,
- Validation of reperfusion modulation after ischemia to reduce lesion size and cell death,
- In vivo characterization of the rat model of neonatal stroke. Efficacy and safety analyses of reperfusion modulation strategies.
Data obtained in that study could also provide interesting breakthroughs for therapeutic strategy in the juvenile and/or mature brain against cerebral stroke.